Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2242878..2243392 Replicon chromosome
Accession NZ_CP094765
Organism Staphylococcus aureus strain IVB6215

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag MUA45_RS11295 Protein ID WP_000581791.1
Coordinates 2242878..2243087 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA45_RS11300 Protein ID WP_000138934.1
Coordinates 2243099..2243392 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA45_RS11270 (MUA45_11265) 2238235..2239437 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA45_RS11275 (MUA45_11270) 2239598..2239807 - 210 Protein_2181 transposase -
MUA45_RS11280 (MUA45_11275) 2239869..2241515 - 1647 WP_000277709.1 IS1182-like element ISSau3 family transposase -
MUA45_RS11285 (MUA45_11280) 2241792..2242201 - 410 Protein_2183 transposase -
MUA45_RS11290 (MUA45_11285) 2242613..2242750 - 138 WP_000828354.1 Lmo0850 family protein -
MUA45_RS11295 (MUA45_11290) 2242878..2243087 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
MUA45_RS11300 (MUA45_11295) 2243099..2243392 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA45_RS11305 (MUA45_11300) 2243558..2245042 + 1485 WP_000571560.1 cardiolipin synthase -
MUA45_RS11310 (MUA45_11305) 2245070..2245717 + 648 WP_001187612.1 HD domain-containing protein -
MUA45_RS11315 (MUA45_11310) 2246430..2247302 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA45_RS11320 (MUA45_11315) 2247388..2248029 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T240261 WP_000581791.1 NZ_CP094765:c2243087-2242878 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240261 NZ_LS992185:576110-576460 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240261 WP_000138934.1 NZ_CP094765:c2243392-2243099 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240261 NZ_LS992185:575865-576116 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References