Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2064221..2064997 Replicon chromosome
Accession NZ_CP094765
Organism Staphylococcus aureus strain IVB6215

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUA45_RS10305 Protein ID WP_000031108.1
Coordinates 2064221..2064373 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag MUA45_RS10310 Protein ID WP_001251219.1
Coordinates 2064398..2064997 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA45_RS10290 (MUA45_10285) 2060366..2061187 + 822 WP_000669380.1 RluA family pseudouridine synthase -
MUA45_RS10295 (MUA45_10290) 2061643..2063028 - 1386 WP_262518294.1 class II fumarate hydratase -
MUA45_RS10300 (MUA45_10295) 2063224..2063619 - 396 WP_045179323.1 hypothetical protein -
MUA45_RS10305 (MUA45_10300) 2064221..2064373 - 153 WP_000031108.1 SAS053 family protein Toxin
MUA45_RS10310 (MUA45_10305) 2064398..2064997 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
MUA45_RS10315 (MUA45_10310) 2065156..2065626 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA45_RS10320 (MUA45_10315) 2065631..2066758 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA45_RS10325 (MUA45_10320) 2066909..2067631 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MUA45_RS10330 (MUA45_10325) 2067624..2069081 - 1458 WP_000649898.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T240259 WP_000031108.1 NZ_CP094765:c2064373-2064221 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T240259 NZ_LS992184:c128991-128833 [Citrobacter freundii]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT240259 WP_001251219.1 NZ_CP094765:c2064997-2064398 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT240259 NZ_LS992184:c129259-129035 [Citrobacter freundii]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References