Detailed information of TA system TA240253

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 919378..919855
• Replicon: chromosome
• Accession: NZ_CP094765
• Organism: Staphylococcus aureus strain IVB6215

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUA45_RS04505
• Protein ID: WP_000052076.1
• Coordinates: 919378..919566 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA45_RS04510
• Protein ID: WP_001059690.1
• Coordinates: 919595..919855 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA45_RS04475 (MUA45_04470)	915331..915888	+	558	WP_045178710.1	hypothetical protein	-
MUA45_RS04480 (MUA45_04475)	916229..916915	+	687	WP_001574556.1	thermonuclease family protein	-
MUA45_RS04485 (MUA45_04480)	917272..917472	+	201	WP_001059082.1	cold-shock protein	-
MUA45_RS04490 (MUA45_04485)	917969..918187	-	219	WP_000005879.1	hypothetical protein	-
MUA45_RS04495 (MUA45_04490)	918249..918533	-	285	WP_001004401.1	hypothetical protein	-
MUA45_RS04500 (MUA45_04495)	918621..919190	-	570	WP_001106663.1	lipoprotein N-acylation protein LnsA	-
MUA45_RS04505 (MUA45_04500)	919378..919566	-	189	WP_000052076.1	hypothetical protein	Toxin
MUA45_RS04510 (MUA45_04505)	919595..919855	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA45_RS04515 (MUA45_04510)	920196..920399	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUA45_RS04520 (MUA45_04515)	920396..920632	-	237	WP_000368687.1	hypothetical protein	-
MUA45_RS04525 (MUA45_04520)	920857..921438	+	582	WP_001140696.1	histidine phosphatase family protein	-
MUA45_RS04530 (MUA45_04525)	921511..922128	-	618	WP_000255548.1	LysE/ArgO family amino acid transporter	-
MUA45_RS04535 (MUA45_04530)	922284..922778	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
MUA45_RS04540 (MUA45_04535)	923177..923599	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
MUA45_RS04545 (MUA45_04540)	923747..924463	+	717	WP_000150025.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-68)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240253 WP_000052076.1 NZ_CP094765:c919566-919378 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240253 NZ_LS992183:c4314506-4314222 [Citrobacter freundii]
ATGACTTATGAACTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATACGGTGAAGGCTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCAGATTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGACCGTGTTTGTTGTCGCGGTCGGCAAA
CGAGAACATTCGGCCGTTTATCTCGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240253 WP_001059690.1 NZ_CP094765:c919855-919595 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240253 NZ_LS992183:c4314738-4314496 [Citrobacter freundii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
ATCGGAAGCTGTGCGATTACTGTTTCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACCGTTAGCGACT
GCGAAGATACACTGATTCAGACAGTCCGGGAGAGGCTGGCCAGCCCGCAAAAAGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56