Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2141061..2141590 Replicon chromosome
Accession NZ_CP094763
Organism Staphylococcus aureus strain IVB6221

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA83_RS10575 Protein ID WP_000621175.1
Coordinates 2141061..2141423 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag MUA83_RS10580 Protein ID WP_000948331.1
Coordinates 2141420..2141590 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA83_RS10555 (MUA83_10550) 2138039..2138809 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
MUA83_RS10560 (MUA83_10555) 2138784..2139263 - 480 WP_001190825.1 anti-sigma B factor RsbW -
MUA83_RS10565 (MUA83_10560) 2139265..2139591 - 327 WP_001052491.1 anti-sigma factor antagonist -
MUA83_RS10570 (MUA83_10565) 2139710..2140711 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
MUA83_RS10575 (MUA83_10570) 2141061..2141423 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA83_RS10580 (MUA83_10575) 2141420..2141590 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA83_RS10585 (MUA83_10580) 2141675..2142823 - 1149 WP_001281160.1 alanine racemase -
MUA83_RS10590 (MUA83_10585) 2142889..2143248 - 360 WP_000581198.1 holo-ACP synthase -
MUA83_RS10595 (MUA83_10590) 2143252..2143743 - 492 WP_001205919.1 PH domain-containing protein -
MUA83_RS10600 (MUA83_10595) 2143730..2145313 - 1584 WP_262529051.1 PH domain-containing protein -
MUA83_RS10605 (MUA83_10600) 2145306..2145785 - 480 WP_262529053.1 hypothetical protein -
MUA83_RS10610 (MUA83_10605) 2145994..2146554 - 561 WP_001092403.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T240247 WP_000621175.1 NZ_CP094763:c2141423-2141061 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T240247 NZ_LS992183:2091348-2091451 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT240247 WP_000948331.1 NZ_CP094763:c2141590-2141420 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT240247 NZ_LS992183:c2091456-2091313 [Citrobacter freundii]
CAAATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References