Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1983212..1983988 Replicon chromosome
Accession NZ_CP094763
Organism Staphylococcus aureus strain IVB6221

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUA83_RS09665 Protein ID WP_000031108.1
Coordinates 1983212..1983364 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag MUA83_RS09670 Protein ID WP_001251219.1
Coordinates 1983389..1983988 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA83_RS09650 (MUA83_09645) 1979216..1980037 + 822 WP_000669377.1 RluA family pseudouridine synthase -
MUA83_RS09655 (MUA83_09650) 1980487..1981872 - 1386 WP_000116236.1 class II fumarate hydratase -
MUA83_RS09660 (MUA83_09655) 1982068..1982463 - 396 WP_000901023.1 hypothetical protein -
MUA83_RS09665 (MUA83_09660) 1983212..1983364 - 153 WP_000031108.1 SAS053 family protein Toxin
MUA83_RS09670 (MUA83_09665) 1983389..1983988 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
MUA83_RS09675 (MUA83_09670) 1984147..1984617 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA83_RS09680 (MUA83_09675) 1984622..1985749 - 1128 WP_000379981.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA83_RS09685 (MUA83_09680) 1985901..1986623 - 723 WP_262529000.1 amino acid ABC transporter ATP-binding protein -
MUA83_RS09690 (MUA83_09685) 1986616..1988073 - 1458 WP_000649902.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T240246 WP_000031108.1 NZ_CP094763:c1983364-1983212 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T240246 NZ_LS992183:921149-921556 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGTTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCTGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT240246 WP_001251219.1 NZ_CP094763:c1983988-1983389 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT240246 NZ_LS992183:920902-921168 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References