Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 1606734..1607531 | Replicon | chromosome |
| Accession | NZ_CP094763 | ||
| Organism | Staphylococcus aureus strain IVB6221 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | MUA83_RS07795 | Protein ID | WP_000525004.1 |
| Coordinates | 1607070..1607531 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUA83_RS07790 | Protein ID | WP_001260486.1 |
| Coordinates | 1606734..1607057 (+) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA83_RS07740 (MUA83_07735) | 1602469..1603026 | - | 558 | WP_000645049.1 | DUF2815 family protein | - |
| MUA83_RS07745 (MUA83_07740) | 1603053..1604219 | - | 1167 | WP_233665663.1 | DUF2800 domain-containing protein | - |
| MUA83_RS07750 (MUA83_07745) | 1604216..1604578 | - | 363 | WP_000985986.1 | hypothetical protein | - |
| MUA83_RS07755 (MUA83_07750) | 1604593..1604916 | - | 324 | WP_000175000.1 | hypothetical protein | - |
| MUA83_RS07760 (MUA83_07755) | 1604995..1605156 | - | 162 | WP_001285954.1 | DUF1270 domain-containing protein | - |
| MUA83_RS07765 (MUA83_07760) | 1605169..1605432 | - | 264 | WP_001124160.1 | helix-turn-helix domain-containing protein | - |
| MUA83_RS07770 (MUA83_07765) | 1605457..1605672 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| MUA83_RS07775 (MUA83_07770) | 1605727..1606092 | + | 366 | WP_001128433.1 | hypothetical protein | - |
| MUA83_RS07780 (MUA83_07775) | 1606061..1606306 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| MUA83_RS07785 (MUA83_07780) | 1606322..1606570 | - | 249 | WP_000272861.1 | helix-turn-helix domain-containing protein | - |
| MUA83_RS07790 (MUA83_07785) | 1606734..1607057 | + | 324 | WP_001260486.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MUA83_RS07795 (MUA83_07790) | 1607070..1607531 | + | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| MUA83_RS07800 (MUA83_07795) | 1607549..1607983 | + | 435 | WP_031903825.1 | hypothetical protein | - |
| MUA83_RS07805 (MUA83_07800) | 1608011..1608406 | + | 396 | WP_001558060.1 | hypothetical protein | - |
| MUA83_RS07810 (MUA83_07805) | 1608514..1608705 | + | 192 | WP_262528755.1 | hypothetical protein | - |
| MUA83_RS07815 (MUA83_07810) | 1608702..1609280 | - | 579 | WP_252559441.1 | hypothetical protein | - |
| MUA83_RS07820 (MUA83_07815) | 1609406..1610611 | + | 1206 | WP_000264747.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1563908..1629973 | 66065 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T240245 WP_000525004.1 NZ_CP094763:1607070-1607531 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T240245 NZ_LS992183:c420871-420554 [Citrobacter freundii]
ATGTTCACATTTATTGAGCTACAAGGATTTAGTAAACGCCGTCCGTTACTTTTGCCTGACGATGAGTTTCGCGCTTTTCA
AGAGGCGCTTATAGAGAACCCTGAGGCTGGAGATACTATCGCTGGTACAGGTGGATTCAGAAAAATTCGCTGGAGTCGCT
CTGGTATGGGCAAACGCAGCGGTATTAGGGTTATCTATTACAACGTGACGCGCAAAGGTCGAATCTATCTCGCTTTGCTC
TATCCTAAAAATGAACAGGATGATTTAACCGAAGAGCAAAAAAGAGTTTTAATGCACTTATCCAATATGCTGATTTAA
ATGTTCACATTTATTGAGCTACAAGGATTTAGTAAACGCCGTCCGTTACTTTTGCCTGACGATGAGTTTCGCGCTTTTCA
AGAGGCGCTTATAGAGAACCCTGAGGCTGGAGATACTATCGCTGGTACAGGTGGATTCAGAAAAATTCGCTGGAGTCGCT
CTGGTATGGGCAAACGCAGCGGTATTAGGGTTATCTATTACAACGTGACGCGCAAAGGTCGAATCTATCTCGCTTTGCTC
TATCCTAAAAATGAACAGGATGATTTAACCGAAGAGCAAAAAAGAGTTTTAATGCACTTATCCAATATGCTGATTTAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12427.10 Da Isoelectric Point: 9.3811
>AT240245 WP_001260486.1 NZ_CP094763:1606734-1607057 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT240245 NZ_LS992183:c420501-420205 [Citrobacter freundii]
ATGAAAGACGAATTATTTGCCGATTTGCTGGCCAGTGCAGAAGAAATGGTGCGTATAGAGAAAGGTGAAGAAACACCTAA
GCCTGAACATGTACATACCTTTAGCGAAATTGATGTTAAAGCCATCCGCGAAGCAACAGGGTTACGCCAACAGGATTTTG
CCATAGCTGTTGGCGTGAGTTATGACCTGGTTAAAAGCTGGGAAACGAAACGACGCCAGCCGACTGGTGCACCAAGAAAA
CTGCTTTTATTAATTCAAAAAAATCCATTTATAATTAATCAATTAAAAGCAATTTAA
ATGAAAGACGAATTATTTGCCGATTTGCTGGCCAGTGCAGAAGAAATGGTGCGTATAGAGAAAGGTGAAGAAACACCTAA
GCCTGAACATGTACATACCTTTAGCGAAATTGATGTTAAAGCCATCCGCGAAGCAACAGGGTTACGCCAACAGGATTTTG
CCATAGCTGTTGGCGTGAGTTATGACCTGGTTAAAAGCTGGGAAACGAAACGACGCCAGCCGACTGGTGCACCAAGAAAA
CTGCTTTTATTAATTCAAAAAAATCCATTTATAATTAATCAATTAAAAGCAATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|