Detailed information of TA system TA240241

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 895006..895483
• Replicon: chromosome
• Accession: NZ_CP094763
• Organism: Staphylococcus aureus strain IVB6221

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUA83_RS04350
• Protein ID: WP_000052076.1
• Coordinates: 895006..895194 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA83_RS04355
• Protein ID: WP_001059690.1
• Coordinates: 895223..895483 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA83_RS04320 (MUA83_04315)	890995..891516	+	522	WP_000824476.1	hypothetical protein	-
MUA83_RS04325 (MUA83_04320)	891857..892543	+	687	WP_000141556.1	thermonuclease family protein	-
MUA83_RS04330 (MUA83_04325)	892900..893100	+	201	WP_001059082.1	cold-shock protein	-
MUA83_RS04335 (MUA83_04330)	893597..893815	-	219	WP_000005883.1	hypothetical protein	-
MUA83_RS04340 (MUA83_04335)	893877..894161	-	285	WP_001004401.1	hypothetical protein	-
MUA83_RS04345 (MUA83_04340)	894249..894818	-	570	WP_001106648.1	lipoprotein N-acylation protein LnsA	-
MUA83_RS04350 (MUA83_04345)	895006..895194	-	189	WP_000052076.1	hypothetical protein	Toxin
MUA83_RS04355 (MUA83_04350)	895223..895483	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA83_RS04360 (MUA83_04355)	895824..896027	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUA83_RS04365 (MUA83_04360)	896024..896260	-	237	WP_000368687.1	hypothetical protein	-
MUA83_RS04370 (MUA83_04365)	896485..897066	+	582	WP_001140696.1	histidine phosphatase family protein	-
MUA83_RS04375 (MUA83_04370)	897139..897756	-	618	WP_000255565.1	LysE/ArgO family amino acid transporter	-
MUA83_RS04380 (MUA83_04375)	897912..898406	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
MUA83_RS04385 (MUA83_04380)	898805..899227	-	423	WP_000974462.1	organic hydroperoxide resistance protein	-
MUA83_RS04390 (MUA83_04385)	899375..900091	+	717	WP_000150032.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-107)

Antitoxin

• HigA2-like, helix-turn-helix domain (8-88)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240241 WP_000052076.1 NZ_CP094763:c895194-895006 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240241 NZ_LS992183:43479-43841 [Citrobacter freundii]
ATGTGGGAAGTGGAAACAACGGATGCTTTCGATAAATGGTTTGACGTACAGACCGAAGCGCTCAAGGAAGATATGCTCGC
AGCAATGATGATTTTATCCGAGTATGGTCCTCAGTTAGGTAGGCCGTTTGCTGATACGGTAAATGCTTCTGCTTTTTCAA
ATATGAAAGAGTTGCGAGTACAGCATCAGGGTAGTCCGATTCGGGCGTTCTTCGCGTTTGATCCTTCTCGCCATGGCATC
GTGCTATGCGCTGGAGATAAAACAGGGTTAAACGAAAAGAAATTCTATAAAGAGATGATCAGGCTTGCGGATGCTGAGTA
CCGAAATCACCTAATAAGTAAGGAAAATTATGGCTACCCTTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240241 WP_001059690.1 NZ_CP094763:c895483-895223 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240241 NZ_LS992183:43828-44127 [Citrobacter freundii]
ATGGCTACCCTTAAAGAATTGATGGCGAAACAAAGCCCGGAAAGCCAGGAGCGTATTACCGAAAAAGTAGAAATACTACG
TCAGGCGGTTGCGTTAAATATGTTAAGGGAAGAACTGAATCTCTCTCAGGCTGAACTTGCCTCGGCAATGGGGGTTAAGC
AGCCAACAATCGCAAAAATGGAGCAGGCAGATAACGATCCTCGTCTGTCGACGCTCAAGCGTTATGTCACGGCACTGGGT
GGTGAACTTAGCATTGATGTTAAGCTACCTACAGGTAAAAGAGTCGCGTTCTATCTTTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56