Detailed information of TA system TA240240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 870340..870872
• Replicon: chromosome
• Accession: NZ_CP094763
• Organism: Staphylococcus aureus strain IVB6221

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q8VLW9
• Locus tag: MUA83_RS04215
• Protein ID: WP_001103944.1
• Coordinates: 870552..870872 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA83_RS04210
• Protein ID: WP_001058486.1
• Coordinates: 870340..870549 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA83_RS04175 (MUA83_04170)	866790..867254	+	465	WP_001085185.1	SsrA-binding protein SmpB	-
MUA83_RS04185 (MUA83_04180)	867818..868924	-	1107	WP_262529681.1	site-specific integrase	-
MUA83_RS04190 (MUA83_04185)	868930..869547	-	618	WP_223200480.1	helix-turn-helix transcriptional regulator	-
MUA83_RS04195 (MUA83_04190)	869735..869941	+	207	WP_001060953.1	hypothetical protein	-
MUA83_RS04200 (MUA83_04195)	869977..870204	+	228	WP_000164237.1	helix-turn-helix transcriptional regulator	-
MUA83_RS04205 (MUA83_04200)	870201..870347	+	147	WP_012990927.1	hypothetical protein	-
MUA83_RS04210 (MUA83_04205)	870340..870549	+	210	WP_001058486.1	hypothetical protein	Antitoxin
MUA83_RS04215 (MUA83_04210)	870552..870872	+	321	WP_001103944.1	DUF1474 family protein	Toxin
MUA83_RS04220 (MUA83_04215)	870939..871808	+	870	WP_262529683.1	primase C-terminal domain-containing protein	-
MUA83_RS04225 (MUA83_04220)	871822..873522	+	1701	WP_262529684.1	DUF927 domain-containing protein	-
MUA83_RS04230 (MUA83_04225)	873851..874231	+	381	WP_000356930.1	hypothetical protein	-
MUA83_RS04235 (MUA83_04230)	874228..874869	+	642	WP_262529686.1	pathogenicity island protein	-
MUA83_RS04240 (MUA83_04235)	875217..875558	+	342	WP_001190600.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12636.31 Da
• Isoelectric Point: 4.8519

>T240240 WP_001103944.1 NZ_CP094763:870552-870872 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFDELIQKF
HEIEKASSDVSLATESDDAKKLKITE

Nucleotide

• Length: 321 bp

>T240240 NZ_LS992182:83873-84178 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT240240 WP_001058486.1 NZ_CP094763:870340-870549 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240240 NZ_LS992182:83653-83871 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Structures

Toxin

• AlphaFold DB: Q8VLW9