Detailed information of TA system TA240239

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 442345..442883
• Replicon: chromosome
• Accession: NZ_CP094763
• Organism: Staphylococcus aureus strain IVB6221

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA83_RS02095
• Protein ID: WP_045178618.1
• Coordinates: 442557..442883 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA83_RS02090
• Protein ID: WP_045178617.1
• Coordinates: 442345..442554 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA83_RS02060 (MUA83_02060)	437869..439410	+	1542	WP_000424963.1	glutamine-hydrolyzing GMP synthase	-
MUA83_RS02065 (MUA83_02065)	439504..440640	-	1137	WP_045178614.1	site-specific integrase	-
MUA83_RS02070 (MUA83_02070)	440724..441509	-	786	WP_165468910.1	helix-turn-helix transcriptional regulator	-
MUA83_RS02075 (MUA83_02075)	441626..441853	+	228	WP_000494396.1	helix-turn-helix transcriptional regulator	-
MUA83_RS02080 (MUA83_02080)	441899..442159	+	261	WP_000080597.1	hypothetical protein	-
MUA83_RS02085 (MUA83_02085)	442206..442352	+	147	WP_172643983.1	hypothetical protein	-
MUA83_RS02090 (MUA83_02090)	442345..442554	+	210	WP_045178617.1	hypothetical protein	Antitoxin
MUA83_RS02095 (MUA83_02095)	442557..442883	+	327	WP_045178618.1	DUF1474 family protein	Toxin
MUA83_RS02100 (MUA83_02100)	442948..443817	+	870	WP_262529511.1	primase C-terminal domain-containing protein	-
MUA83_RS02105 (MUA83_02105)	443834..445291	+	1458	WP_045178620.1	virulence-associated E family protein	-
MUA83_RS02110 (MUA83_02110)	445592..445954	+	363	WP_045178622.1	hypothetical protein	-
MUA83_RS02115 (MUA83_02115)	445956..446240	+	285	WP_045178623.1	hypothetical protein	-
MUA83_RS02120 (MUA83_02120)	446237..446878	+	642	WP_045178624.1	pathogenicity island protein	-
MUA83_RS02125 (MUA83_02125)	447395..447736	+	342	WP_001190600.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	435072..456324	21252

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13165.42 Da
• Isoelectric Point: 4.5527

>T240239 WP_045178618.1 NZ_CP094763:442557-442883 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFEELYPHEPNHNLNKDELIREGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T240239 NZ_LS992182:c76943-76527 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCTGAAGCAGTGCTTAAGAATCT
GGAGCAGGCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGCGCCACCGGTC
CAAAGGCATCGCCACGCCACGTGCAGCTGGTTGACGCGTTCTGCGCCCGTCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGATGCAACCACGGAGGTTAAGGTGGCGCTGCGCCTCGCCGGCACGCCGATCGGTCCAAACGACACGGCGATCGC
CGGGCACGCCATCGCCACCGGGGCAATACTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTGCCTGGACTGGTACTGG
AAGACTGGGCAGGATAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8237.34 Da
• Isoelectric Point: 4.6311

>AT240239 WP_045178617.1 NZ_CP094763:442345-442554 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLKLSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240239 NZ_LS992182:c77170-76940 [Escherichia coli]
ATGAGAACCGTATCTATTTTCAAAAATGGCAATAACCGCGCGATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
TGAGCTGGAGATTGTACGGGAAGGGGACAGAATCATTCTGCGTCCCCTCCGCCCGAGCTGGAGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGGCTTTATGACGGAACGCGAGGACGTTGTCTGCGACGAAGGACGATTTAACCTGTGA