Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2075049..2075563 Replicon chromosome
Accession NZ_CP094760
Organism Staphylococcus aureus strain IVB6232

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MUA14_RS10080 Protein ID WP_000581792.1
Coordinates 2075049..2075258 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MUA14_RS10085 Protein ID WP_252550173.1
Coordinates 2075270..2075563 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA14_RS10060 (MUA14_10050) 2070557..2071915 - 1359 WP_000611474.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUA14_RS10065 (MUA14_10055) 2071930..2073000 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MUA14_RS10070 (MUA14_10060) 2073318..2074520 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA14_RS10075 (MUA14_10065) 2074784..2074921 - 138 WP_000828354.1 Lmo0850 family protein -
MUA14_RS10080 (MUA14_10070) 2075049..2075258 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MUA14_RS10085 (MUA14_10075) 2075270..2075563 - 294 WP_252550173.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA14_RS10090 (MUA14_10080) 2075729..2077213 + 1485 WP_252550175.1 cardiolipin synthase -
MUA14_RS10095 (MUA14_10085) 2077241..2077888 + 648 WP_001187631.1 HD domain-containing protein -
MUA14_RS10100 (MUA14_10090) 2078654..2079526 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA14_RS10105 (MUA14_10095) 2079612..2080253 - 642 WP_000483148.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T240233 WP_000581792.1 NZ_CP094760:c2075258-2075049 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240233 NZ_LS992181:7421-7708 [Escherichia coli]
ATGAGGTATCAGGTAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAAATGGACAAGACTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGCGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCTGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11201.72 Da        Isoelectric Point: 5.6498

>AT240233 WP_252550173.1 NZ_CP094760:c2075563-2075270 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDDYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240233 NZ_LS992181:7173-7424 [Escherichia coli]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAATCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TCGATGCCCTGGACGATCAGGAGCTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGACCTGGAT
AAATACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure

References