Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1897262..1898038 Replicon chromosome
Accession NZ_CP094760
Organism Staphylococcus aureus strain IVB6232

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUA14_RS09080 Protein ID WP_000031108.1
Coordinates 1897262..1897414 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag MUA14_RS09085 Protein ID WP_001251219.1
Coordinates 1897439..1898038 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA14_RS09060 (MUA14_09050) 1893266..1894087 + 822 WP_000669377.1 RluA family pseudouridine synthase -
MUA14_RS09065 (MUA14_09055) 1894537..1895922 - 1386 WP_000116236.1 class II fumarate hydratase -
MUA14_RS09070 (MUA14_09060) 1896118..1896513 - 396 WP_000901023.1 hypothetical protein -
MUA14_RS09075 (MUA14_09065) 1896734..1896871 + 138 WP_162634120.1 hypothetical protein -
MUA14_RS09080 (MUA14_09070) 1897262..1897414 - 153 WP_000031108.1 SAS053 family protein Toxin
MUA14_RS09085 (MUA14_09075) 1897439..1898038 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
MUA14_RS09090 (MUA14_09080) 1898197..1898667 - 471 WP_262541357.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA14_RS09095 (MUA14_09085) 1898672..1899798 - 1127 Protein_1781 tRNA epoxyqueuosine(34) reductase QueG -
MUA14_RS09100 (MUA14_09090) 1899949..1900671 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MUA14_RS09105 (MUA14_09095) 1900664..1902121 - 1458 WP_262541359.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T240231 WP_000031108.1 NZ_CP094760:c1897414-1897262 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T240231 NZ_LS992180:c4611789-4611616 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT240231 WP_001251219.1 NZ_CP094760:c1898038-1897439 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT240231 NZ_LS992180:c4612113-4611817 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References