Detailed information of TA system TA240223

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2037112..2037650
• Replicon: chromosome
• Accession: NZ_CP094758
• Organism: Staphylococcus aureus strain IVB6239

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA67_RS10185
• Protein ID: WP_262610176.1
• Coordinates: 2037112..2037438 (-)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: C5QLS5
• Locus tag: MUA67_RS10190
• Protein ID: WP_001058489.1
• Coordinates: 2037441..2037650 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA67_RS10160 (2032439)	2032439..2032780	-	342	WP_001190600.1	hypothetical protein	-
MUA67_RS10165 (2033127)	2033127..2033768	-	642	WP_262610174.1	pathogenicity island protein	-
MUA67_RS10170 (2033765)	2033765..2034145	-	381	WP_103145486.1	hypothetical protein	-
MUA67_RS10175 (2034453)	2034453..2036162	-	1710	WP_262610175.1	DUF927 domain-containing protein	-
MUA67_RS10180 (2036176)	2036176..2037045	-	870	WP_103145484.1	primase alpha helix C-terminal domain-containing protein	-
MUA67_RS10185 (2037112)	2037112..2037438	-	327	WP_262610176.1	DUF1474 family protein	Toxin
MUA67_RS10190 (2037441)	2037441..2037650	-	210	WP_001058489.1	hypothetical protein	Antitoxin
MUA67_RS10195 (2037643)	2037643..2037789	-	147	WP_000784893.1	hypothetical protein	-
MUA67_RS10200 (2037786)	2037786..2038103	-	318	WP_103145482.1	helix-turn-helix domain-containing protein	-
MUA67_RS10205 (2038107)	2038107..2038319	-	213	WP_103145481.1	helix-turn-helix transcriptional regulator	-
MUA67_RS10210 (2038482)	2038482..2039159	+	678	WP_103145480.1	helix-turn-helix transcriptional regulator	-
MUA67_RS10215 (2039176)	2039176..2040348	+	1173	WP_262610177.1	site-specific integrase	-
MUA67_RS10220 (2040417)	2040417..2042033	-	1617	WP_000240642.1	chaperonin GroEL	-
MUA67_RS10225 (2042109)	2042109..2042393	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	2029680..2045364	15684

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-92)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 13018.41 Da
• Isoelectric Point: 4.6844

>T240223 WP_262610176.1 NZ_CP094758:c2037438-2037112 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFDNFYPHEANHVLNKTEAIKEGLSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSDVSLATESDDAQKLKITE

Nucleotide

• Length: 327 bp

>T240223 NZ_LS992180:c3735930-3735628 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8225.24 Da
• Isoelectric Point: 4.2820

>AT240223 WP_001058489.1 NZ_CP094758:c2037650-2037441 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVDGIEVVSEVSREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240223 NZ_LS992180:c3735592-3735251 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Structures

Antitoxin

• AlphaFold DB: A0A853V601