Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1924336..1925112 Replicon chromosome
Accession NZ_CP094758
Organism Staphylococcus aureus strain IVB6239

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUA67_RS09475 Protein ID WP_000031108.1
Coordinates 1924336..1924488 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA67_RS09480 Protein ID WP_262610111.1
Coordinates 1924513..1925112 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA67_RS09460 (1920306) 1920306..1921127 + 822 WP_000669376.1 RluA family pseudouridine synthase -
MUA67_RS09465 (1921580) 1921580..1922965 - 1386 WP_000116231.1 class II fumarate hydratase -
MUA67_RS09470 (1923161) 1923161..1923556 - 396 WP_262610110.1 hypothetical protein -
MUA67_RS09475 (1924336) 1924336..1924488 - 153 WP_000031108.1 SAS053 family protein Toxin
MUA67_RS09480 (1924513) 1924513..1925112 - 600 WP_262610111.1 glucosamine-6-phosphate isomerase Antitoxin
MUA67_RS09485 (1925270) 1925270..1925740 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA67_RS09490 (1925745) 1925745..1926872 - 1128 WP_262610113.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA67_RS09495 (1927024) 1927024..1927746 - 723 WP_262611706.1 amino acid ABC transporter ATP-binding protein -
MUA67_RS09500 (1927739) 1927739..1929196 - 1458 WP_262610114.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T240222 WP_000031108.1 NZ_CP094758:c1924488-1924336 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T240222 NZ_LS992180:2857539-2857646 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22361.51 Da        Isoelectric Point: 5.1445

>AT240222 WP_262610111.1 NZ_CP094758:c1925112-1924513 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAMELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT240222 NZ_LS992180:c2857482-2857427 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References