Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1551569..1552381 Replicon chromosome
Accession NZ_CP094758
Organism Staphylococcus aureus strain IVB6239

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA67_RS07625 Protein ID WP_262609859.1
Coordinates 1551905..1552381 (+) Length 159 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA67_RS07620 Protein ID WP_045179171.1
Coordinates 1551569..1551892 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA67_RS07545 (1546679) 1546679..1546939 - 261 WP_000291103.1 DUF1108 family protein -
MUA67_RS07550 (1547033) 1547033..1547194 - 162 WP_262609853.1 DUF1270 domain-containing protein -
MUA67_RS07555 (1547206) 1547206..1547469 - 264 WP_001124198.1 helix-turn-helix domain-containing protein -
MUA67_RS07560 (1547619) 1547619..1547717 - 99 Protein_1483 hypothetical protein -
MUA67_RS07565 (1547714) 1547714..1548040 - 327 WP_001025595.1 hypothetical protein -
MUA67_RS07570 (1548367) 1548367..1548606 - 240 WP_001294156.1 hypothetical protein -
MUA67_RS07575 (1548666) 1548666..1548893 + 228 WP_000801108.1 hypothetical protein -
MUA67_RS07580 (1548895) 1548895..1549086 - 192 WP_000389906.1 hypothetical protein -
MUA67_RS07585 (1549143) 1549143..1549352 + 210 WP_000772137.1 hypothetical protein -
MUA67_RS07590 (1549345) 1549345..1549485 - 141 WP_000939495.1 hypothetical protein -
MUA67_RS07595 (1549501) 1549501..1550253 - 753 WP_001148605.1 phage antirepressor KilAC domain-containing protein -
MUA67_RS07600 (1550309) 1550309..1550548 + 240 WP_262609855.1 hypothetical protein -
MUA67_RS07605 (1550738) 1550738..1550968 + 231 WP_000549548.1 hypothetical protein -
MUA67_RS07610 (1550965) 1550965..1551141 - 177 WP_001001356.1 hypothetical protein -
MUA67_RS07615 (1551157) 1551157..1551405 - 249 WP_000272859.1 helix-turn-helix transcriptional regulator -
MUA67_RS07620 (1551569) 1551569..1551892 + 324 WP_045179171.1 helix-turn-helix transcriptional regulator Antitoxin
MUA67_RS07625 (1551905) 1551905..1552381 + 477 WP_262609859.1 toxin Toxin
MUA67_RS07630 (1552382) 1552382..1553050 + 669 WP_262609860.1 Ltp family lipoprotein -
MUA67_RS07635 (1553202) 1553202..1553384 + 183 WP_000705246.1 hypothetical protein -
MUA67_RS07640 (1553527) 1553527..1553754 - 228 WP_162646301.1 hypothetical protein -
MUA67_RS07645 (1554260) 1554260..1555465 + 1206 WP_000264190.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / gnd 1513517..1578050 64533


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 159 a.a.        Molecular weight: 18712.19 Da        Isoelectric Point: 4.6091

>T240221 WP_262609859.1 NZ_CP094758:1551905-1552381 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSIFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAINYYKKIYGIGTHYGEYSITFEPLRVFKYKKLFEEDI

Download         Length: 477 bp

>T240221 NZ_LS992180:2548835-2550157 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCAGCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTACGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGATCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12489.13 Da        Isoelectric Point: 8.4338

>AT240221 WP_045179171.1 NZ_CP094758:1551569-1551892 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANELKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT240221 NZ_LS992180:2548569-2548835 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References