Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 863351..863828 | Replicon | chromosome |
| Accession | NZ_CP094758 | ||
| Organism | Staphylococcus aureus strain IVB6239 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | MUA67_RS04240 | Protein ID | WP_000052076.1 |
| Coordinates | 863351..863539 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | MUA67_RS04245 | Protein ID | WP_001059690.1 |
| Coordinates | 863568..863828 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA67_RS04210 (859355) | 859355..859864 | + | 510 | WP_262611271.1 | hypothetical protein | - |
| MUA67_RS04215 (860205) | 860205..860891 | + | 687 | WP_262611272.1 | thermonuclease family protein | - |
| MUA67_RS04220 (861248) | 861248..861448 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| MUA67_RS04225 (861942) | 861942..862160 | - | 219 | WP_262611274.1 | hypothetical protein | - |
| MUA67_RS04230 (862222) | 862222..862506 | - | 285 | WP_001004399.1 | hypothetical protein | - |
| MUA67_RS04235 (862594) | 862594..863163 | - | 570 | WP_262611276.1 | lipoprotein N-acylation protein LnsA | - |
| MUA67_RS04240 (863351) | 863351..863539 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| MUA67_RS04245 (863568) | 863568..863828 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| MUA67_RS04250 (864168) | 864168..864371 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| MUA67_RS04255 (864368) | 864368..864604 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| MUA67_RS04260 (864828) | 864828..865409 | + | 582 | WP_262611278.1 | histidine phosphatase family protein | - |
| MUA67_RS04265 (865482) | 865482..866099 | - | 618 | WP_000255554.1 | LysE/ArgO family amino acid transporter | - |
| MUA67_RS04270 (866254) | 866254..866748 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| MUA67_RS04275 (867147) | 867147..867569 | - | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| MUA67_RS04280 (867717) | 867717..868433 | + | 717 | WP_262611280.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T240215 WP_000052076.1 NZ_CP094758:c863539-863351 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T240215 NZ_LS992180:c885962-885585 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCAACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT240215 WP_001059690.1 NZ_CP094758:c863828-863568 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT240215 NZ_LS992180:c886419-886039 [Escherichia coli]
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACTCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
ATGTCGGACACACTCCCCGGAACAACGCTTCCCGACGACAACAAAGACCTCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
ACCTTGTTTTGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGGGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACTCTCGGGTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |