Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2153456..2153970 Replicon chromosome
Accession NZ_CP094755
Organism Staphylococcus aureus strain IVB6242

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag MUA32_RS10735 Protein ID WP_000581791.1
Coordinates 2153456..2153665 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA32_RS10740 Protein ID WP_000138934.1
Coordinates 2153677..2153970 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA32_RS10715 (2149345) 2149345..2150415 - 1071 WP_000159638.1 D-alanine--D-alanine ligase -
MUA32_RS10720 (2150733) 2150733..2151935 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA32_RS10725 (2152096) 2152096..2152779 - 684 Protein_2071 transposase -
MUA32_RS10730 (2153191) 2153191..2153328 - 138 WP_000828354.1 Lmo0850 family protein -
MUA32_RS10735 (2153456) 2153456..2153665 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
MUA32_RS10740 (2153677) 2153677..2153970 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA32_RS10745 (2154136) 2154136..2155620 + 1485 WP_000571560.1 cardiolipin synthase -
MUA32_RS10750 (2155648) 2155648..2156295 + 648 WP_001187612.1 HD domain-containing protein -
MUA32_RS10755 (2156908) 2156908..2157780 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA32_RS10760 (2157866) 2157866..2158507 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2152096..2152272 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T240202 WP_000581791.1 NZ_CP094755:c2153665-2153456 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240202 NZ_LS992175:3865606-3865824 [Citrobacter freundii]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240202 WP_000138934.1 NZ_CP094755:c2153970-2153677 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240202 NZ_LS992175:3865204-3865578 [Citrobacter freundii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References