Detailed information of TA system TA240200

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2080304..2080818
• Replicon: chromosome
• Accession: NZ_CP094755
• Organism: Staphylococcus aureus strain IVB6242

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA32_RS10370
• Protein ID: WP_262515866.1
• Coordinates: 2080304..2080606 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA32_RS10375
• Protein ID: WP_262515867.1
• Coordinates: 2080603..2080818 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA32_RS10340 (2075453)	2075453..2076031	-	579	WP_262515861.1	pathogenicity island protein	-
MUA32_RS10345 (2076043)	2076043..2076384	-	342	WP_001190600.1	hypothetical protein	-
MUA32_RS10350 (2076732)	2076732..2077373	-	642	WP_262515863.1	pathogenicity island protein	-
MUA32_RS10355 (2077375)	2077375..2077647	-	273	WP_111762498.1	pathogenicity island protein	-
MUA32_RS10360 (2077634)	2077634..2078437	-	804	WP_000148373.1	bifunctional DNA primase/polymerase	-
MUA32_RS10365 (2078613)	2078613..2080229	-	1617	WP_262515864.1	phage resistance protein	-
MUA32_RS10370 (2080304)	2080304..2080606	-	303	WP_262515866.1	DUF1474 family protein	Toxin
MUA32_RS10375 (2080603)	2080603..2080818	-	216	WP_262515867.1	pathogenicity island protein	Antitoxin
MUA32_RS10380 (2080811)	2080811..2080957	-	147	WP_000784893.1	hypothetical protein	-
MUA32_RS10385 (2080954)	2080954..2081271	-	318	WP_000481969.1	helix-turn-helix domain-containing protein	-
MUA32_RS10390 (2081287)	2081287..2081487	-	201	WP_111762499.1	helix-turn-helix transcriptional regulator	-
MUA32_RS10395 (2081650)	2081650..2082327	+	678	WP_111762500.1	helix-turn-helix transcriptional regulator	-
MUA32_RS10400 (2082344)	2082344..2083516	+	1173	WP_111762501.1	tyrosine-type recombinase/integrase	-
MUA32_RS10405 (2083585)	2083585..2085201	-	1617	WP_262515869.1	chaperonin GroEL	-
MUA32_RS10410 (2085277)	2085277..2085561	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	2062996..2085561	22565

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 12181.39 Da
• Isoelectric Point: 4.6906

>T240200 WP_262515866.1 NZ_CP094755:c2080606-2080304 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFDNFYPHEPNHVLNKTEAIKEGLSYHERRIHNNQMFDLFHLYIEQFDKIIE
KFHEIEKASSENFGEESDDA

Nucleotide

• Length: 303 bp

>T240200 NZ_LS992175:933650-934057 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCTGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8494.58 Da
• Isoelectric Point: 4.5099

>AT240200 WP_262515867.1 NZ_CP094755:c2080818-2080603 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGEQK

Nucleotide

• Length: 216 bp

>AT240200 NZ_LS992175:933403-933669 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGACATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA