Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1994208..1995005 Replicon chromosome
Accession NZ_CP094755
Organism Staphylococcus aureus strain IVB6242

Toxin (Protein)


Gene name - Uniprot ID A0A641AAS6
Locus tag MUA32_RS09915 Protein ID WP_000525006.1
Coordinates 1994544..1995005 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag MUA32_RS09910 Protein ID WP_001260487.1
Coordinates 1994208..1994531 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA32_RS09860 (1989873) 1989873..1990424 - 552 WP_000704705.1 single-stranded DNA-binding protein -
MUA32_RS09865 (1990455) 1990455..1991243 - 789 WP_029625654.1 ATP-binding protein -
MUA32_RS09870 (1991236) 1991236..1991457 - 222 WP_001077279.1 DUF2483 family protein -
MUA32_RS09875 (1991467) 1991467..1991727 - 261 WP_262515835.1 DUF1108 family protein -
MUA32_RS09880 (1991732) 1991732..1992035 - 304 Protein_1907 DUF2482 family protein -
MUA32_RS09885 (1992138) 1992138..1992299 - 162 WP_000048121.1 DUF1270 family protein -
MUA32_RS09890 (1992292) 1992292..1992513 - 222 WP_000977378.1 hypothetical protein -
MUA32_RS09895 (1992585) 1992585..1992815 + 231 WP_000395455.1 hypothetical protein -
MUA32_RS09900 (1992982) 1992982..1993779 - 798 WP_262515840.1 phage antirepressor KilAC domain-containing protein -
MUA32_RS09905 (1993795) 1993795..1994043 - 249 WP_262515396.1 helix-turn-helix transcriptional regulator -
MUA32_RS09910 (1994208) 1994208..1994531 + 324 WP_001260487.1 helix-turn-helix transcriptional regulator Antitoxin
MUA32_RS09915 (1994544) 1994544..1995005 + 462 WP_000525006.1 hypothetical protein Toxin
MUA32_RS09920 (1995143) 1995143..1996048 + 906 WP_000391592.1 hypothetical protein -
MUA32_RS09925 (1995985) 1995985..1996185 - 201 WP_000143212.1 excisionase -
MUA32_RS09930 (1996297) 1996297..1997343 + 1047 WP_262515844.1 site-specific integrase -
MUA32_RS09935 (1997388) 1997388..1998533 + 1146 WP_106905529.1 radical SAM/CxCxxxxC motif protein YfkAB -
MUA32_RS09940 (1998793) 1998793..1999323 - 531 WP_000184383.1 acyl-CoA thioesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1953784..1997343 43559


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18118.47 Da        Isoelectric Point: 4.6915

>T240199 WP_000525006.1 NZ_CP094755:1994544-1995005 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Download         Length: 462 bp

>T240199 NZ_LS992175:c367657-367340 [Citrobacter freundii]
ATGTTCACATTTATTGAGCTACAAGGATTTAGTAAACGCCGTCCGTTACTTTTGCCTGACGATGAGTTTCGCGCTTTTCA
AGAGGCGCTTATAGAGAACCCTGAGGCTGGAGATACTATCGCTGGTACAGGTGGATTCAGAAAAATTCGCTGGAGTCGCT
CTGGTATGGGCAAACGCAGCGGTATTAGGGTTATCTATTACAACGTGACGCGCAAAGGTCGAATCTATCTCGCTTTGCTC
TATCCTAAAAATGAACAGGATGATTTAACCGAAGAGCAAAAAAGAGTTTTAATGCACTTATCCAATATGCTGATTTAA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT240199 WP_001260487.1 NZ_CP094755:1994208-1994531 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT240199 NZ_LS992175:c367287-366991 [Citrobacter freundii]
ATGAAAGACGAATTATTTGCCGATTTGCTGGCCAGTGCAGAAGAAATGGTGCGTATAGAGAAAGGTGAAGAAACACCTAA
GCCTGAACATGTACATACCTTTAGCGAAATTGATGTTAAAGCCATCCGCGAAGCAACAGGGTTACGCCAACAGGATTTTG
CCATAGCTGTTGGCGTGAGTTATGACCTGGTTAAAAGCTGGGAAACGAAACGACGCCAGCCGACTGGTGCACCAAGAAAA
CTGCTTTTATTAATTCAAAAAAATCCATTTATAATTAATCAATTAAAAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641AAS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References