Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TscAT/-
Location 875366..875904 Replicon chromosome
Accession NZ_CP094755
Organism Staphylococcus aureus strain IVB6242

Toxin (Protein)


Gene name TscT Uniprot ID -
Locus tag MUA32_RS04240 Protein ID WP_262516296.1
Coordinates 875578..875904 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name TscA Uniprot ID -
Locus tag MUA32_RS04235 Protein ID WP_250406114.1
Coordinates 875366..875575 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA32_RS04200 (871229) 871229..872449 - 1221 WP_262515151.1 site-specific integrase -
MUA32_RS04205 (872660) 872660..873340 - 681 WP_262516294.1 type II toxin-antitoxin system PemK/MazF family toxin -
MUA32_RS04210 (873480) 873480..873647 - 168 WP_031806878.1 hypothetical protein -
MUA32_RS04215 (873844) 873844..874482 - 639 WP_250406350.1 XRE family transcriptional regulator -
MUA32_RS04220 (874673) 874673..874927 + 255 WP_250425964.1 helix-turn-helix transcriptional regulator -
MUA32_RS04225 (874943) 874943..875215 + 273 WP_250425965.1 helix-turn-helix domain-containing protein -
MUA32_RS04230 (875227) 875227..875373 + 147 WP_250406348.1 pathogenicity island protein -
MUA32_RS04235 (875366) 875366..875575 + 210 WP_250406114.1 pathogenicity island protein Antitoxin
MUA32_RS04240 (875578) 875578..875904 + 327 WP_262516296.1 DUF1474 family protein Toxin
MUA32_RS04245 (875969) 875969..876838 + 870 WP_262516297.1 primase alpha helix C-terminal domain-containing protein -
MUA32_RS04250 (876855) 876855..878324 + 1470 WP_262516298.1 virulence-associated E family protein -
MUA32_RS04255 (878604) 878604..878966 + 363 WP_045178622.1 hypothetical protein -
MUA32_RS04260 (878968) 878968..879231 + 264 WP_001804819.1 hypothetical protein -
MUA32_RS04265 (879233) 879233..879874 + 642 WP_252580283.1 pathogenicity island protein -
MUA32_RS04270 (880221) 880221..880562 + 342 WP_262516299.1 pathogenicity island protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 853345..885731 32386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1474

(1-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12978.31 Da        Isoelectric Point: 4.7152

>T240195 WP_262516296.1 NZ_CP094755:875578-875904 [Staphylococcus aureus]
MNLEINDLFSDLKLLKDRFEDLKDNHGWHFDNFYPHEPNHVLNKTEAIKEGLSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Download         Length: 327 bp

>T240195 NZ_LS992172:c71784-71626 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 8220.25 Da        Isoelectric Point: 4.3718

>AT240195 WP_250406114.1 NZ_CP094755:875366-875575 [Staphylococcus aureus]
MNNEQKEVLEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELILKWCAQELKNNFQLEKGE

Download         Length: 210 bp

>AT240195 NZ_LS992172:c72052-71828 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References