Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsdAT/- |
| Location | 2153453..2153967 | Replicon | chromosome |
| Accession | NZ_CP094752 | ||
| Organism | Staphylococcus aureus strain IVB6243 | ||
Toxin (Protein)
| Gene name | TsdT | Uniprot ID | A0A7U7IDH9 |
| Locus tag | MUA86_RS10735 | Protein ID | WP_000581791.1 |
| Coordinates | 2153453..2153662 (-) | Length | 70 a.a. |
Antitoxin (Protein)
| Gene name | TsdA | Uniprot ID | A0A0D1GBN9 |
| Locus tag | MUA86_RS10740 | Protein ID | WP_000138934.1 |
| Coordinates | 2153674..2153967 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA86_RS10715 (2149342) | 2149342..2150412 | - | 1071 | WP_000159638.1 | D-alanine--D-alanine ligase | - |
| MUA86_RS10720 (2150730) | 2150730..2151932 | + | 1203 | WP_001109939.1 | FtsW/RodA/SpoVE family cell cycle protein | - |
| MUA86_RS10725 (2152093) | 2152093..2152776 | - | 684 | Protein_2071 | transposase | - |
| MUA86_RS10730 (2153188) | 2153188..2153325 | - | 138 | WP_000828354.1 | Lmo0850 family protein | - |
| MUA86_RS10735 (2153453) | 2153453..2153662 | - | 210 | WP_000581791.1 | heavy metal-associated domain-containing protein | Toxin |
| MUA86_RS10740 (2153674) | 2153674..2153967 | - | 294 | WP_000138934.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
| MUA86_RS10745 (2154133) | 2154133..2155617 | + | 1485 | WP_000571560.1 | cardiolipin synthase | - |
| MUA86_RS10750 (2155645) | 2155645..2156292 | + | 648 | WP_001187612.1 | HD domain-containing protein | - |
| MUA86_RS10755 (2156449) | 2156449..2156748 | + | 300 | WP_001793952.1 | hypothetical protein | - |
| MUA86_RS10760 (2156905) | 2156905..2157777 | - | 873 | WP_000725802.1 | membrane protein insertase YidC | - |
| MUA86_RS10765 (2157863) | 2157863..2158504 | - | 642 | WP_000483150.1 | thiamine phosphate synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2152093..2152269 | 176 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 70 a.a. Molecular weight: 7826.83 Da Isoelectric Point: 4.1008
>T240184 WP_000581791.1 NZ_CP094752:c2153662-2153453 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF
Download Length: 210 bp
>T240184 NZ_LS992171:2649063-2649170 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11185.77 Da Isoelectric Point: 6.2243
>AT240184 WP_000138934.1 NZ_CP094752:c2153967-2153674 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
Download Length: 294 bp
>AT240184 NZ_LS992171:c2649016-2648950 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7U7IDH9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0D1GBN9 |