Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2153453..2153967 Replicon chromosome
Accession NZ_CP094752
Organism Staphylococcus aureus strain IVB6243

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag MUA86_RS10735 Protein ID WP_000581791.1
Coordinates 2153453..2153662 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA86_RS10740 Protein ID WP_000138934.1
Coordinates 2153674..2153967 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA86_RS10715 (2149342) 2149342..2150412 - 1071 WP_000159638.1 D-alanine--D-alanine ligase -
MUA86_RS10720 (2150730) 2150730..2151932 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA86_RS10725 (2152093) 2152093..2152776 - 684 Protein_2071 transposase -
MUA86_RS10730 (2153188) 2153188..2153325 - 138 WP_000828354.1 Lmo0850 family protein -
MUA86_RS10735 (2153453) 2153453..2153662 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
MUA86_RS10740 (2153674) 2153674..2153967 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA86_RS10745 (2154133) 2154133..2155617 + 1485 WP_000571560.1 cardiolipin synthase -
MUA86_RS10750 (2155645) 2155645..2156292 + 648 WP_001187612.1 HD domain-containing protein -
MUA86_RS10755 (2156449) 2156449..2156748 + 300 WP_001793952.1 hypothetical protein -
MUA86_RS10760 (2156905) 2156905..2157777 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA86_RS10765 (2157863) 2157863..2158504 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2152093..2152269 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T240184 WP_000581791.1 NZ_CP094752:c2153662-2153453 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240184 NZ_LS992171:2649063-2649170 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240184 WP_000138934.1 NZ_CP094752:c2153967-2153674 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240184 NZ_LS992171:c2649016-2648950 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References