Detailed information of TA system TA240182

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2080301..2080815
• Replicon: chromosome
• Accession: NZ_CP094752
• Organism: Staphylococcus aureus strain IVB6243

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA86_RS10370
• Protein ID: WP_262515866.1
• Coordinates: 2080301..2080603 (-)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA86_RS10375
• Protein ID: WP_262515867.1
• Coordinates: 2080600..2080815 (-)
• Length: 72 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA86_RS10340 (2075450)	2075450..2076028	-	579	WP_262515861.1	pathogenicity island protein	-
MUA86_RS10345 (2076040)	2076040..2076381	-	342	WP_001190600.1	hypothetical protein	-
MUA86_RS10350 (2076729)	2076729..2077370	-	642	WP_262515863.1	pathogenicity island protein	-
MUA86_RS10355 (2077372)	2077372..2077644	-	273	WP_111762498.1	pathogenicity island protein	-
MUA86_RS10360 (2077631)	2077631..2078434	-	804	WP_000148373.1	bifunctional DNA primase/polymerase	-
MUA86_RS10365 (2078610)	2078610..2080226	-	1617	WP_262515864.1	phage resistance protein	-
MUA86_RS10370 (2080301)	2080301..2080603	-	303	WP_262515866.1	DUF1474 family protein	Toxin
MUA86_RS10375 (2080600)	2080600..2080815	-	216	WP_262515867.1	pathogenicity island protein	Antitoxin
MUA86_RS10380 (2080808)	2080808..2080954	-	147	WP_000784893.1	hypothetical protein	-
MUA86_RS10385 (2080951)	2080951..2081268	-	318	WP_000481969.1	helix-turn-helix domain-containing protein	-
MUA86_RS10390 (2081284)	2081284..2081484	-	201	WP_111762499.1	helix-turn-helix transcriptional regulator	-
MUA86_RS10395 (2081647)	2081647..2082324	+	678	WP_111762500.1	helix-turn-helix transcriptional regulator	-
MUA86_RS10400 (2082341)	2082341..2083513	+	1173	WP_111762501.1	tyrosine-type recombinase/integrase	-
MUA86_RS10405 (2083582)	2083582..2085198	-	1617	WP_262515869.1	chaperonin GroEL	-
MUA86_RS10410 (2085274)	2085274..2085558	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	groEL	2062993..2085558	22565

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 12181.39 Da
• Isoelectric Point: 4.6906

>T240182 WP_262515866.1 NZ_CP094752:c2080603-2080301 [Staphylococcus aureus]
MNWEINDLFSDLKVLKDRFEDLKDNHGWHFDNFYPHEPNHVLNKTEAIKEGLSYHERRIHNNQMFDLFHLYIEQFDKIIE
KFHEIEKASSENFGEESDDA

Nucleotide

• Length: 303 bp

>T240182 NZ_LS992171:c2435922-2435746 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 72 a.a.
• Molecular weight: 8494.58 Da
• Isoelectric Point: 4.5099

>AT240182 WP_262515867.1 NZ_CP094752:c2080815-2080600 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGEQK

Nucleotide

• Length: 216 bp

>AT240182 NZ_LS992171:c2435700-2435284 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA