Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1994205..1995002 Replicon chromosome
Accession NZ_CP094752
Organism Staphylococcus aureus strain IVB6243

Toxin (Protein)


Gene name - Uniprot ID A0A641AAS6
Locus tag MUA86_RS09915 Protein ID WP_000525006.1
Coordinates 1994541..1995002 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0C2LD36
Locus tag MUA86_RS09910 Protein ID WP_001260487.1
Coordinates 1994205..1994528 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA86_RS09860 (1989870) 1989870..1990421 - 552 WP_000704705.1 single-stranded DNA-binding protein -
MUA86_RS09865 (1990452) 1990452..1991240 - 789 WP_029625654.1 ATP-binding protein -
MUA86_RS09870 (1991233) 1991233..1991454 - 222 WP_001077279.1 DUF2483 family protein -
MUA86_RS09875 (1991464) 1991464..1991724 - 261 WP_262515835.1 DUF1108 family protein -
MUA86_RS09880 (1991729) 1991729..1992032 - 304 Protein_1907 DUF2482 family protein -
MUA86_RS09885 (1992135) 1992135..1992296 - 162 WP_000048121.1 DUF1270 family protein -
MUA86_RS09890 (1992289) 1992289..1992510 - 222 WP_000977378.1 hypothetical protein -
MUA86_RS09895 (1992582) 1992582..1992812 + 231 WP_000395455.1 hypothetical protein -
MUA86_RS09900 (1992979) 1992979..1993776 - 798 WP_262515840.1 phage antirepressor KilAC domain-containing protein -
MUA86_RS09905 (1993792) 1993792..1994040 - 249 WP_262515396.1 helix-turn-helix transcriptional regulator -
MUA86_RS09910 (1994205) 1994205..1994528 + 324 WP_001260487.1 helix-turn-helix transcriptional regulator Antitoxin
MUA86_RS09915 (1994541) 1994541..1995002 + 462 WP_000525006.1 hypothetical protein Toxin
MUA86_RS09920 (1995140) 1995140..1996045 + 906 WP_000391592.1 hypothetical protein -
MUA86_RS09925 (1995982) 1995982..1996182 - 201 WP_000143212.1 excisionase -
MUA86_RS09930 (1996294) 1996294..1997340 + 1047 WP_262515844.1 site-specific integrase -
MUA86_RS09935 (1997385) 1997385..1998530 + 1146 WP_106905529.1 radical SAM/CxCxxxxC motif protein YfkAB -
MUA86_RS09940 (1998790) 1998790..1999320 - 531 WP_000184383.1 acyl-CoA thioesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1953781..1997340 43559


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18118.47 Da        Isoelectric Point: 4.6915

>T240181 WP_000525006.1 NZ_CP094752:1994541-1995002 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVYRYKEI

Download         Length: 462 bp

>T240181 NZ_LS992171:2329782-2331104 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCAAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCCAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATACCCGAAGA
CGAAACCGTAACGCATCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGCTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACAGCACTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCA
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAAGCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12431.09 Da        Isoelectric Point: 9.3811

>AT240181 WP_001260487.1 NZ_CP094752:1994205-1994528 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT240181 NZ_LS992171:2329516-2329782 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGTATTAAGCAGGCGACGATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAAATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A641AAS6

Antitoxin

Source ID Structure
AlphaFold DB A0A0C2LD36

References