240176

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 858745..859222 Replicon chromosome
Accession NZ_CP094752
Organism Staphylococcus aureus strain IVB6243

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MUA86_RS04105 Protein ID WP_000052076.1
Coordinates 858745..858933 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MUA86_RS04110 Protein ID WP_001059690.1
Coordinates 858962..859222 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA86_RS04075 (854698) 854698..855255 + 558 WP_000824491.1 hypothetical protein -
MUA86_RS04080 (855596) 855596..856282 + 687 WP_001574556.1 thermonuclease family protein -
MUA86_RS04085 (856639) 856639..856839 + 201 WP_001059082.1 cold-shock protein -
MUA86_RS04090 (857336) 857336..857554 - 219 WP_000005879.1 hypothetical protein -
MUA86_RS04095 (857616) 857616..857900 - 285 WP_001004401.1 hypothetical protein -
MUA86_RS04100 (857988) 857988..858557 - 570 WP_001106663.1 lipoprotein N-acylation protein LnsA -
MUA86_RS04105 (858745) 858745..858933 - 189 WP_000052076.1 hypothetical protein Toxin
MUA86_RS04110 (858962) 858962..859222 - 261 WP_001059690.1 hypothetical protein Antitoxin
MUA86_RS04115 (859563) 859563..859766 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MUA86_RS04120 (859763) 859763..859999 - 237 WP_000368687.1 hypothetical protein -
MUA86_RS04125 (860224) 860224..860805 + 582 WP_001140696.1 histidine phosphatase family protein -
MUA86_RS04130 (860878) 860878..861495 - 618 WP_000255548.1 LysE/ArgO family amino acid transporter -
MUA86_RS04135 (861651) 861651..862145 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
MUA86_RS04140 (862544) 862544..862966 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
MUA86_RS04145 (863114) 863114..863830 + 717 WP_000150025.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 853342..885728 32386


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)

Antitoxin

Toxin YoeB

(5-84)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T240176 WP_000052076.1 NZ_CP094752:c858933-858745 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T240176 NZ_LS992171:1786028-1786279 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT240176 WP_001059690.1 NZ_CP094752:c859222-858962 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT240176 NZ_LS992171:1786276-1786530 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCTCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCTACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References