Detailed information of TA system TA240165

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_XRE(antitoxin)
• Location: 1584093..1584890
• Replicon: chromosome
• Accession: NZ_CP094750
• Organism: Staphylococcus aureus strain IVB6248

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MUA07_RS07620
• Protein ID: WP_262541840.1
• Coordinates: 1584429..1584890 (+)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MUA07_RS07615
• Protein ID: WP_001260486.1
• Coordinates: 1584093..1584416 (+)
• Length: 108 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA07_RS07565 (MUA07_07565)	1579828..1580385	-	558	WP_000645049.1	DUF2815 family protein	-
MUA07_RS07570 (MUA07_07570)	1580412..1581578	-	1167	WP_262541838.1	DUF2800 domain-containing protein	-
MUA07_RS07575 (MUA07_07575)	1581575..1581937	-	363	WP_000985986.1	hypothetical protein	-
MUA07_RS07580 (MUA07_07580)	1581952..1582275	-	324	WP_000175000.1	hypothetical protein	-
MUA07_RS07585 (MUA07_07585)	1582354..1582515	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
MUA07_RS07590 (MUA07_07590)	1582528..1582791	-	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
MUA07_RS07595 (MUA07_07595)	1582816..1583031	-	216	WP_001097552.1	hypothetical protein	-
MUA07_RS07600 (MUA07_07600)	1583086..1583451	+	366	WP_001128433.1	hypothetical protein	-
MUA07_RS07605 (MUA07_07605)	1583420..1583665	-	246	WP_001025401.1	DUF2829 domain-containing protein	-
MUA07_RS07610 (MUA07_07610)	1583681..1583929	-	249	WP_000272861.1	helix-turn-helix domain-containing protein	-
MUA07_RS07615 (MUA07_07615)	1584093..1584416	+	324	WP_001260486.1	helix-turn-helix transcriptional regulator	Antitoxin
MUA07_RS07620 (MUA07_07620)	1584429..1584890	+	462	WP_262541840.1	toxin	Toxin
MUA07_RS07625 (MUA07_07625)	1584908..1585342	+	435	WP_031903825.1	hypothetical protein	-
MUA07_RS07630 (MUA07_07630)	1585370..1585765	+	396	WP_001558060.1	hypothetical protein	-
MUA07_RS07635 (MUA07_07635)	1585873..1586064	+	192	WP_252559444.1	hypothetical protein	-
MUA07_RS07640 (MUA07_07640)	1586061..1586639	-	579	WP_252559441.1	hypothetical protein	-
MUA07_RS07645 (MUA07_07645)	1586765..1587970	+	1206	WP_000264747.1	site-specific integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1541295..1600726	59431

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (8-65)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18062.40 Da
• Isoelectric Point: 4.6915

>T240165 WP_262541840.1 NZ_CP094750:1584429-1584890 [Staphylococcus aureus]
MGLYEETLIQHDYIETREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T240165 NZ_LS992169:42166-42324 [Escherichia coli]
ATGAAACTACCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGCTGTGCGAGATTCGTTACAGAGACGGACACAGGGAGGTGGCGGCTTTCATGGCTTACGAATCCGGTAAGTAG

Antitoxin

Protein

• Length: 108 a.a.
• Molecular weight: 12427.10 Da
• Isoelectric Point: 9.3811

>AT240165 WP_001260486.1 NZ_CP094750:1584093-1584416 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 324 bp

>AT240165 NZ_LS992169:42082-42122 [Escherichia coli]
TTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT