Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 872552..873029 | Replicon | chromosome |
| Accession | NZ_CP094750 | ||
| Organism | Staphylococcus aureus strain IVB6248 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | MUA07_RS04180 | Protein ID | WP_000052076.1 |
| Coordinates | 872552..872740 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | MUA07_RS04185 | Protein ID | WP_001059690.1 |
| Coordinates | 872769..873029 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA07_RS04150 (MUA07_04150) | 868541..869062 | + | 522 | WP_000824476.1 | hypothetical protein | - |
| MUA07_RS04155 (MUA07_04155) | 869403..870089 | + | 687 | WP_262542240.1 | thermonuclease family protein | - |
| MUA07_RS04160 (MUA07_04160) | 870446..870646 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| MUA07_RS04165 (MUA07_04165) | 871143..871361 | - | 219 | WP_000005883.1 | hypothetical protein | - |
| MUA07_RS04170 (MUA07_04170) | 871423..871707 | - | 285 | WP_001004401.1 | hypothetical protein | - |
| MUA07_RS04175 (MUA07_04175) | 871795..872364 | - | 570 | WP_001106648.1 | lipoprotein N-acylation protein LnsA | - |
| MUA07_RS04180 (MUA07_04180) | 872552..872740 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| MUA07_RS04185 (MUA07_04185) | 872769..873029 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| MUA07_RS04190 (MUA07_04190) | 873370..873573 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| MUA07_RS04195 (MUA07_04195) | 873570..873806 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| MUA07_RS04200 (MUA07_04200) | 874031..874612 | + | 582 | WP_001140696.1 | histidine phosphatase family protein | - |
| MUA07_RS04205 (MUA07_04205) | 874685..875302 | - | 618 | WP_000255565.1 | LysE/ArgO family amino acid transporter | - |
| MUA07_RS04210 (MUA07_04210) | 875458..875952 | - | 495 | WP_000569881.1 | GNAT family N-acetyltransferase | - |
| MUA07_RS04215 (MUA07_04215) | 876351..876773 | - | 423 | WP_262542243.1 | organic hydroperoxide resistance protein | - |
| MUA07_RS04220 (MUA07_04220) | 876921..877637 | + | 717 | WP_262542244.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 867186..897212 | 30026 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T240161 WP_000052076.1 NZ_CP094750:c872740-872552 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T240161 NZ_LS992168:c4302889-4302512 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCAGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT240161 WP_001059690.1 NZ_CP094750:c873029-872769 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT240161 NZ_LS992168:c4303347-4302979 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |