Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2190542..2191056 Replicon chromosome
Accession NZ_CP094747
Organism Staphylococcus aureus strain IVB6249

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag MUA08_RS10960 Protein ID WP_000581791.1
Coordinates 2190542..2190751 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA08_RS10965 Protein ID WP_000138934.1
Coordinates 2190763..2191056 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA08_RS10935 (MUA08_10935) 2185899..2187101 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA08_RS10940 (MUA08_10940) 2187262..2187471 - 210 Protein_2115 transposase -
MUA08_RS10945 (MUA08_10945) 2187533..2189179 - 1647 WP_000277709.1 IS1182-like element ISSau3 family transposase -
MUA08_RS10950 (MUA08_10950) 2189456..2189865 - 410 Protein_2117 transposase -
MUA08_RS10955 (MUA08_10955) 2190277..2190414 - 138 WP_000828354.1 Lmo0850 family protein -
MUA08_RS10960 (MUA08_10960) 2190542..2190751 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
MUA08_RS10965 (MUA08_10965) 2190763..2191056 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA08_RS10970 (MUA08_10970) 2191222..2192706 + 1485 WP_000571560.1 cardiolipin synthase -
MUA08_RS10975 (MUA08_10975) 2192734..2193381 + 648 WP_001187612.1 HD domain-containing protein -
MUA08_RS10980 (MUA08_10980) 2193638..2193937 + 300 WP_001793952.1 hypothetical protein -
MUA08_RS10985 (MUA08_10985) 2194094..2194966 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA08_RS10990 (MUA08_10990) 2195052..2195693 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T240156 WP_000581791.1 NZ_CP094747:c2190751-2190542 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240156 NZ_LS992168:3659955-3660173 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240156 WP_000138934.1 NZ_CP094747:c2191056-2190763 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240156 NZ_LS992168:3659555-3659929 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References