Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2011887..2012663 Replicon chromosome
Accession NZ_CP094747
Organism Staphylococcus aureus strain IVB6249

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUA08_RS09970 Protein ID WP_000031108.1
Coordinates 2011887..2012039 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag MUA08_RS09975 Protein ID WP_001251219.1
Coordinates 2012064..2012663 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA08_RS09955 (MUA08_09955) 2008032..2008853 + 822 WP_000669380.1 RluA family pseudouridine synthase -
MUA08_RS09960 (MUA08_09960) 2009309..2010694 - 1386 WP_262518294.1 class II fumarate hydratase -
MUA08_RS09965 (MUA08_09965) 2010890..2011285 - 396 WP_045179323.1 hypothetical protein -
MUA08_RS09970 (MUA08_09970) 2011887..2012039 - 153 WP_000031108.1 SAS053 family protein Toxin
MUA08_RS09975 (MUA08_09975) 2012064..2012663 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
MUA08_RS09980 (MUA08_09980) 2012822..2013292 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA08_RS09985 (MUA08_09985) 2013297..2014424 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA08_RS09990 (MUA08_09990) 2014575..2015297 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MUA08_RS09995 (MUA08_09995) 2015290..2016747 - 1458 WP_000649898.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T240154 WP_000031108.1 NZ_CP094747:c2012039-2011887 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T240154 NZ_LS992168:2748722-2748829 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT240154 WP_001251219.1 NZ_CP094747:c2012663-2012064 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT240154 NZ_LS992168:c2748665-2748610 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References