Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tsbAT/- |
| Location | 2011887..2012663 | Replicon | chromosome |
| Accession | NZ_CP094747 | ||
| Organism | Staphylococcus aureus strain IVB6249 | ||
Toxin (Protein)
| Gene name | tsbT | Uniprot ID | X5E2E6 |
| Locus tag | MUA08_RS09970 | Protein ID | WP_000031108.1 |
| Coordinates | 2011887..2012039 (-) | Length | 51 a.a. |
Antitoxin (Protein)
| Gene name | tsbA | Uniprot ID | A0A0D1IYN8 |
| Locus tag | MUA08_RS09975 | Protein ID | WP_001251219.1 |
| Coordinates | 2012064..2012663 (-) | Length | 200 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA08_RS09955 (MUA08_09955) | 2008032..2008853 | + | 822 | WP_000669380.1 | RluA family pseudouridine synthase | - |
| MUA08_RS09960 (MUA08_09960) | 2009309..2010694 | - | 1386 | WP_262518294.1 | class II fumarate hydratase | - |
| MUA08_RS09965 (MUA08_09965) | 2010890..2011285 | - | 396 | WP_045179323.1 | hypothetical protein | - |
| MUA08_RS09970 (MUA08_09970) | 2011887..2012039 | - | 153 | WP_000031108.1 | SAS053 family protein | Toxin |
| MUA08_RS09975 (MUA08_09975) | 2012064..2012663 | - | 600 | WP_001251219.1 | glucosamine-6-phosphate isomerase | Antitoxin |
| MUA08_RS09980 (MUA08_09980) | 2012822..2013292 | - | 471 | WP_000181394.1 | tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL | - |
| MUA08_RS09985 (MUA08_09985) | 2013297..2014424 | - | 1128 | WP_000379980.1 | tRNA epoxyqueuosine(34) reductase QueG | - |
| MUA08_RS09990 (MUA08_09990) | 2014575..2015297 | - | 723 | WP_000590809.1 | amino acid ABC transporter ATP-binding protein | - |
| MUA08_RS09995 (MUA08_09995) | 2015290..2016747 | - | 1458 | WP_000649898.1 | ABC transporter permease subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5936.28 Da Isoelectric Point: 3.8962
>T240154 WP_000031108.1 NZ_CP094747:c2012039-2011887 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ
Download Length: 153 bp
>T240154 NZ_LS992168:2748722-2748829 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACAACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGTGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 200 a.a. Molecular weight: 22357.50 Da Isoelectric Point: 5.1445
>AT240154 WP_001251219.1 NZ_CP094747:c2012663-2012064 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA
Download Length: 600 bp
>AT240154 NZ_LS992168:c2748665-2748610 [Escherichia coli]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTC
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | X5E2E6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0D1IYN8 |