Detailed information of TA system TA240148

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 867388..867865
• Replicon: chromosome
• Accession: NZ_CP094747
• Organism: Staphylococcus aureus strain IVB6249

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUA08_RS04185
• Protein ID: WP_000052076.1
• Coordinates: 867388..867576 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA08_RS04190
• Protein ID: WP_001059690.1
• Coordinates: 867605..867865 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA08_RS04155 (MUA08_04160)	863341..863898	+	558	WP_045178710.1	hypothetical protein	-
MUA08_RS04160 (MUA08_04165)	864239..864925	+	687	WP_001574556.1	thermonuclease family protein	-
MUA08_RS04165 (MUA08_04170)	865282..865482	+	201	WP_001059082.1	cold-shock protein	-
MUA08_RS04170 (MUA08_04175)	865979..866197	-	219	WP_000005879.1	hypothetical protein	-
MUA08_RS04175 (MUA08_04180)	866259..866543	-	285	WP_001004401.1	hypothetical protein	-
MUA08_RS04180 (MUA08_04185)	866631..867200	-	570	WP_001106663.1	lipoprotein N-acylation protein LnsA	-
MUA08_RS04185 (MUA08_04190)	867388..867576	-	189	WP_000052076.1	hypothetical protein	Toxin
MUA08_RS04190 (MUA08_04195)	867605..867865	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA08_RS04195 (MUA08_04200)	868206..868409	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUA08_RS04200 (MUA08_04205)	868406..868642	-	237	WP_000368687.1	hypothetical protein	-
MUA08_RS04205 (MUA08_04210)	868867..869448	+	582	WP_001140696.1	histidine phosphatase family protein	-
MUA08_RS04210 (MUA08_04215)	869521..870138	-	618	WP_000255548.1	LysE/ArgO family amino acid transporter	-
MUA08_RS04215 (MUA08_04220)	870294..870788	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
MUA08_RS04220 (MUA08_04225)	871187..871609	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
MUA08_RS04225 (MUA08_04230)	871757..872473	+	717	WP_000150025.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240148 WP_000052076.1 NZ_CP094747:c867576-867388 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240148 NZ_LS992168:963477-963884 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATTCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240148 WP_001059690.1 NZ_CP094747:c867865-867605 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240148 NZ_LS992168:963230-963496 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCACCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56