Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2176983..2177497 Replicon chromosome
Accession NZ_CP094745
Organism Staphylococcus aureus strain IVB6250

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag MUA64_RS10860 Protein ID WP_000581791.1
Coordinates 2176983..2177192 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA64_RS10865 Protein ID WP_000138934.1
Coordinates 2177204..2177497 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA64_RS10835 (MUA64_10835) 2172340..2173542 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA64_RS10840 (MUA64_10840) 2173703..2173912 - 210 Protein_2095 transposase -
MUA64_RS10845 (MUA64_10845) 2173974..2175620 - 1647 WP_000277709.1 IS1182-like element ISSau3 family transposase -
MUA64_RS10850 (MUA64_10850) 2175897..2176306 - 410 Protein_2097 transposase -
MUA64_RS10855 (MUA64_10855) 2176718..2176855 - 138 WP_000828354.1 Lmo0850 family protein -
MUA64_RS10860 (MUA64_10860) 2176983..2177192 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
MUA64_RS10865 (MUA64_10865) 2177204..2177497 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA64_RS10870 (MUA64_10870) 2177663..2179147 + 1485 WP_000571560.1 cardiolipin synthase -
MUA64_RS10875 (MUA64_10875) 2179175..2179822 + 648 WP_001187612.1 HD domain-containing protein -
MUA64_RS10880 (MUA64_10880) 2180535..2181407 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA64_RS10885 (MUA64_10885) 2181493..2182134 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T240144 WP_000581791.1 NZ_CP094745:c2177192-2176983 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240144 NZ_LS992168:288521-289048 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCATT
AAATCTCTTTCTGACGACACATCTGGTTCGTCAACATCGCAATAAAATTCTGCGAGCGTATATCCTGTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATCCGGCAGTTGTTTTGAACGAGCCGCACTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTAACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTTGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATGAAAAAGCCCATACGTTTTATCAGTCGCTGGGCTTTATCCCATTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCGACCAAATCTATAGAGCTACTTTTTACACCAGACGATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240144 WP_000138934.1 NZ_CP094745:c2177497-2177204 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240144 NZ_LS992168:288248-288514 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATTGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGAGCTGCGGAAGTGATTGAACAGCATCGGCGGA
TGATTCTCACTGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCAGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References