Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1998326..1999102 Replicon chromosome
Accession NZ_CP094745
Organism Staphylococcus aureus strain IVB6250

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUA64_RS09870 Protein ID WP_000031108.1
Coordinates 1998326..1998478 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID A0A0D1IYN8
Locus tag MUA64_RS09875 Protein ID WP_001251219.1
Coordinates 1998503..1999102 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA64_RS09855 (MUA64_09855) 1994471..1995292 + 822 WP_000669380.1 RluA family pseudouridine synthase -
MUA64_RS09860 (MUA64_09860) 1995748..1997133 - 1386 WP_262518294.1 class II fumarate hydratase -
MUA64_RS09865 (MUA64_09865) 1997329..1997724 - 396 WP_045179323.1 hypothetical protein -
MUA64_RS09870 (MUA64_09870) 1998326..1998478 - 153 WP_000031108.1 SAS053 family protein Toxin
MUA64_RS09875 (MUA64_09875) 1998503..1999102 - 600 WP_001251219.1 glucosamine-6-phosphate isomerase Antitoxin
MUA64_RS09880 (MUA64_09880) 1999261..1999731 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA64_RS09885 (MUA64_09885) 1999736..2000863 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA64_RS09890 (MUA64_09890) 2001014..2001736 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MUA64_RS09895 (MUA64_09895) 2001729..2003186 - 1458 WP_000649898.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T240142 WP_000031108.1 NZ_CP094745:c1998478-1998326 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T240142 NZ_LS992168:185540-185647 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22357.50 Da        Isoelectric Point: 5.1445

>AT240142 WP_001251219.1 NZ_CP094745:c1999102-1998503 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT240142 NZ_LS992168:c185491-185426 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1IYN8

References