Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 853825..854302 | Replicon | chromosome |
| Accession | NZ_CP094745 | ||
| Organism | Staphylococcus aureus strain IVB6250 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | MUA64_RS04085 | Protein ID | WP_000052076.1 |
| Coordinates | 853825..854013 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | MUA64_RS04090 | Protein ID | WP_001059690.1 |
| Coordinates | 854042..854302 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA64_RS04055 (MUA64_04060) | 849778..850335 | + | 558 | WP_045178710.1 | hypothetical protein | - |
| MUA64_RS04060 (MUA64_04065) | 850676..851362 | + | 687 | WP_001574556.1 | thermonuclease family protein | - |
| MUA64_RS04065 (MUA64_04070) | 851719..851919 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| MUA64_RS04070 (MUA64_04075) | 852416..852634 | - | 219 | WP_000005879.1 | hypothetical protein | - |
| MUA64_RS04075 (MUA64_04080) | 852696..852980 | - | 285 | WP_001004401.1 | hypothetical protein | - |
| MUA64_RS04080 (MUA64_04085) | 853068..853637 | - | 570 | WP_001106663.1 | lipoprotein N-acylation protein LnsA | - |
| MUA64_RS04085 (MUA64_04090) | 853825..854013 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| MUA64_RS04090 (MUA64_04095) | 854042..854302 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| MUA64_RS04095 (MUA64_04100) | 854643..854846 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| MUA64_RS04100 (MUA64_04105) | 854843..855079 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| MUA64_RS04105 (MUA64_04110) | 855304..855885 | + | 582 | WP_001140696.1 | histidine phosphatase family protein | - |
| MUA64_RS04110 (MUA64_04115) | 855958..856575 | - | 618 | WP_000255548.1 | LysE/ArgO family amino acid transporter | - |
| MUA64_RS04115 (MUA64_04120) | 856731..857225 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| MUA64_RS04120 (MUA64_04125) | 857624..858046 | - | 423 | WP_000974455.1 | organic hydroperoxide resistance protein | - |
| MUA64_RS04125 (MUA64_04130) | 858194..858910 | + | 717 | WP_000150025.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T240136 WP_000052076.1 NZ_CP094745:c854013-853825 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T240136 NZ_LS992166:c4200488-4200114 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAATGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT240136 WP_001059690.1 NZ_CP094745:c854302-854042 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT240136 NZ_LS992166:c4200946-4200578 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGAACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGAACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |