Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2138020..2138534 Replicon chromosome
Accession NZ_CP094743
Organism Staphylococcus aureus strain IVB6252

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MUA62_RS10490 Protein ID WP_000581792.1
Coordinates 2138020..2138229 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MUA62_RS10495 Protein ID WP_000138934.1
Coordinates 2138241..2138534 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA62_RS10470 (MUA62_10470) 2133528..2134886 - 1359 WP_000611474.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUA62_RS10475 (MUA62_10475) 2134901..2135971 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MUA62_RS10480 (MUA62_10480) 2136289..2137491 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUA62_RS10485 (MUA62_10485) 2137755..2137892 - 138 WP_000828354.1 Lmo0850 family protein -
MUA62_RS10490 (MUA62_10490) 2138020..2138229 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MUA62_RS10495 (MUA62_10495) 2138241..2138534 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA62_RS10500 (MUA62_10500) 2138700..2140184 + 1485 WP_262541900.1 cardiolipin synthase -
MUA62_RS10505 (MUA62_10505) 2140212..2140859 + 648 WP_001187631.1 HD domain-containing protein -
MUA62_RS10510 (MUA62_10510) 2141625..2142497 - 873 WP_000725802.1 membrane protein insertase YidC -
MUA62_RS10515 (MUA62_10515) 2142583..2143224 - 642 WP_000483148.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T240131 WP_000581792.1 NZ_CP094743:c2138229-2138020 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240131 NZ_LS992166:2761265-2761372 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT240131 WP_000138934.1 NZ_CP094743:c2138534-2138241 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240131 NZ_LS992166:c2761218-2761152 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References