240128

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1583955..1584752 Replicon chromosome
Accession NZ_CP094743
Organism Staphylococcus aureus strain IVB6252

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA62_RS07620 Protein ID WP_262541840.1
Coordinates 1584291..1584752 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA62_RS07615 Protein ID WP_001260486.1
Coordinates 1583955..1584278 (+) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA62_RS07565 (MUA62_07565) 1579690..1580247 - 558 WP_000645049.1 DUF2815 family protein -
MUA62_RS07570 (MUA62_07570) 1580274..1581440 - 1167 WP_262612649.1 DUF2800 domain-containing protein -
MUA62_RS07575 (MUA62_07575) 1581437..1581799 - 363 WP_000985986.1 hypothetical protein -
MUA62_RS07580 (MUA62_07580) 1581814..1582137 - 324 WP_000175000.1 hypothetical protein -
MUA62_RS07585 (MUA62_07585) 1582216..1582377 - 162 WP_001285954.1 DUF1270 domain-containing protein -
MUA62_RS07590 (MUA62_07590) 1582390..1582653 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
MUA62_RS07595 (MUA62_07595) 1582678..1582893 - 216 WP_001097552.1 hypothetical protein -
MUA62_RS07600 (MUA62_07600) 1582948..1583313 + 366 WP_001128433.1 hypothetical protein -
MUA62_RS07605 (MUA62_07605) 1583282..1583527 - 246 WP_001025401.1 DUF2829 domain-containing protein -
MUA62_RS07610 (MUA62_07610) 1583543..1583791 - 249 WP_000272861.1 helix-turn-helix domain-containing protein -
MUA62_RS07615 (MUA62_07615) 1583955..1584278 + 324 WP_001260486.1 helix-turn-helix transcriptional regulator Antitoxin
MUA62_RS07620 (MUA62_07620) 1584291..1584752 + 462 WP_262541840.1 toxin Toxin
MUA62_RS07625 (MUA62_07625) 1584770..1585204 + 435 WP_031903825.1 hypothetical protein -
MUA62_RS07630 (MUA62_07630) 1585232..1585627 + 396 WP_001558060.1 hypothetical protein -
MUA62_RS07635 (MUA62_07635) 1585735..1585926 + 192 WP_252559444.1 hypothetical protein -
MUA62_RS07640 (MUA62_07640) 1585923..1586501 - 579 WP_252559441.1 hypothetical protein -
MUA62_RS07645 (MUA62_07645) 1586627..1587832 + 1206 WP_000264747.1 site-specific integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1541157..1600588 59431


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(8-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18062.40 Da        Isoelectric Point: 4.6915

>T240128 WP_262541840.1 NZ_CP094743:1584291-1584752 [Staphylococcus aureus]
MGLYEETLIQHDYIETREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T240128 NZ_LS992166:2382037-2382324 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12427.10 Da        Isoelectric Point: 9.3811

>AT240128 WP_001260486.1 NZ_CP094743:1583955-1584278 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK

Download         Length: 324 bp

>AT240128 NZ_LS992166:2381798-2382037 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References