Detailed information of TA system TA240124

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 872415..872892
• Replicon: chromosome
• Accession: NZ_CP094743
• Organism: Staphylococcus aureus strain IVB6252

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUA62_RS04180
• Protein ID: WP_000052076.1
• Coordinates: 872415..872603 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUA62_RS04185
• Protein ID: WP_001059690.1
• Coordinates: 872632..872892 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA62_RS04150 (MUA62_04150)	868404..868925	+	522	WP_000824476.1	hypothetical protein	-
MUA62_RS04155 (MUA62_04155)	869266..869952	+	687	WP_262542240.1	thermonuclease family protein	-
MUA62_RS04160 (MUA62_04160)	870309..870509	+	201	WP_001059082.1	cold-shock protein	-
MUA62_RS04165 (MUA62_04165)	871006..871224	-	219	WP_000005883.1	hypothetical protein	-
MUA62_RS04170 (MUA62_04170)	871286..871570	-	285	WP_001004401.1	hypothetical protein	-
MUA62_RS04175 (MUA62_04175)	871658..872227	-	570	WP_001106648.1	lipoprotein N-acylation protein LnsA	-
MUA62_RS04180 (MUA62_04180)	872415..872603	-	189	WP_000052076.1	hypothetical protein	Toxin
MUA62_RS04185 (MUA62_04185)	872632..872892	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUA62_RS04190 (MUA62_04190)	873233..873436	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUA62_RS04195 (MUA62_04195)	873433..873669	-	237	WP_000368687.1	hypothetical protein	-
MUA62_RS04200 (MUA62_04200)	873894..874475	+	582	WP_001140696.1	histidine phosphatase family protein	-
MUA62_RS04205 (MUA62_04205)	874548..875165	-	618	WP_000255565.1	LysE/ArgO family amino acid transporter	-
MUA62_RS04210 (MUA62_04210)	875321..875815	-	495	WP_000569881.1	GNAT family N-acetyltransferase	-
MUA62_RS04215 (MUA62_04215)	876214..876636	-	423	WP_262542243.1	organic hydroperoxide resistance protein	-
MUA62_RS04220 (MUA62_04220)	876784..877500	+	717	WP_262542244.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	867049..897075	30026

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (10-109)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240124 WP_000052076.1 NZ_CP094743:c872603-872415 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240124 NZ_LS992166:1077013-1077348 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240124 WP_001059690.1 NZ_CP094743:c872892-872632 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240124 NZ_LS992166:1076765-1077013 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56