Detailed information of TA system TA240122

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 873031..873812
• Replicon: chromosome
• Accession: NZ_CP094742
• Organism: Staphylococcus chromogenes strain IVB6199

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MUA20_RS04435
• Protein ID: WP_157946118.1
• Coordinates: 873648..873812 (+)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MUA20_RS04430
• Protein ID: WP_105986518.1
• Coordinates: 873031..873630 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA20_RS04410 (MUA20_04380)	869313..869938	+	626	Protein_834	amino acid ABC transporter ATP-binding protein	-
MUA20_RS04415 (MUA20_04385)	870225..871358	+	1134	WP_262621824.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA20_RS04420 (MUA20_04390)	871355..871825	+	471	WP_262621825.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA20_RS04425 (MUA20_04395)	871843..873012	+	1170	WP_262621826.1	N-acetylglucosamine-6-phosphate deacetylase	-
MUA20_RS04430 (MUA20_04400)	873031..873630	+	600	WP_105986518.1	glucosamine-6-phosphate isomerase	Antitoxin
MUA20_RS04435 (MUA20_04405)	873648..873812	+	165	WP_157946118.1	SAS053 family protein	Toxin
MUA20_RS04440 (MUA20_04410)	873912..874322	+	411	WP_262621827.1	hypothetical protein	-
MUA20_RS04445 (MUA20_04415)	874467..875852	+	1386	WP_262621828.1	class II fumarate hydratase	-
MUA20_RS04450 (MUA20_04420)	875874..877400	+	1527	WP_262621829.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (135-197)

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6306.69 Da
• Isoelectric Point: 3.9165

>T240122 WP_157946118.1 NZ_CP094742:873648-873812 [Staphylococcus chromogenes]
MTEEKHIEHENEMVDDFDDLVSLGKEMEQISEANDEEKVNQTHDASIRSDKTEE

Nucleotide

• Length: 165 bp

>T240122 NZ_LS992166:c829703-829329 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22354.27 Da
• Isoelectric Point: 5.8826

>AT240122 WP_105986518.1 NZ_CP094742:873031-873630 [Staphylococcus chromogenes]
MAMNFKVFKDKDTAAIYAADIIRKQFNNNPTTIAGFHLSGEEAPVLDYLKRNVDDHAVDFSQIHVLDYDKQTSYFKALGV
PEKQIHEIPEDDDVEKFIEHKAKTKDNKGKLTLQVVSINQNGEFGVPVNNGLKPAREIFVIVTGHDKADVIKKLYEDNGN
TSFIPSSLKTHRMVNVILDEAAAQGLPADVREYFTSLYA

Nucleotide

• Length: 600 bp

>AT240122 NZ_LS992166:c830161-829793 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA