Detailed information of TA system TA240120

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 975997..976778
• Replicon: chromosome
• Accession: NZ_CP094741
• Organism: Staphylococcus chromogenes strain IVB6200

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: MUA19_RS04685
• Protein ID: WP_157946118.1
• Coordinates: 976614..976778 (+)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: MUA19_RS04680
• Protein ID: WP_262617389.1
• Coordinates: 975997..976596 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA19_RS04660 (MUA19_04645)	972181..972903	+	723	WP_262617384.1	amino acid ABC transporter ATP-binding protein	-
MUA19_RS04665 (MUA19_04650)	973191..974324	+	1134	WP_262617386.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUA19_RS04670 (MUA19_04655)	974321..974791	+	471	WP_232195961.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUA19_RS04675 (MUA19_04660)	974809..975978	+	1170	WP_262617388.1	N-acetylglucosamine-6-phosphate deacetylase	-
MUA19_RS04680 (MUA19_04665)	975997..976596	+	600	WP_262617389.1	glucosamine-6-phosphate isomerase	Antitoxin
MUA19_RS04685 (MUA19_04670)	976614..976778	+	165	WP_157946118.1	SAS053 family protein	Toxin
MUA19_RS04690 (MUA19_04675)	977317..977727	+	411	WP_105986519.1	hypothetical protein	-
MUA19_RS04695 (MUA19_04680)	977872..979257	+	1386	WP_262617392.1	class II fumarate hydratase	-
MUA19_RS04700 (MUA19_04685)	979279..980805	+	1527	WP_262617393.1	exopolyphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (135-197)

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6306.69 Da
• Isoelectric Point: 3.9165

>T240120 WP_157946118.1 NZ_CP094741:976614-976778 [Staphylococcus chromogenes]
MTEEKHIEHENEMVDDFDDLVSLGKEMEQISEANDEEKVNQTHDASIRSDKTEE

Nucleotide

• Length: 165 bp

>T240120 NZ_LS992166:670345-670659 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22353.33 Da
• Isoelectric Point: 6.3860

>AT240120 WP_262617389.1 NZ_CP094741:975997-976596 [Staphylococcus chromogenes]
MAMNFKVFKDKDTAAIYAADIIRKQFNNNPTTIAGFHLSGEEAPVLDYLKRNVDDHAVDFSQIHVLDYDKQTSYFKALGV
PEKQIHKIPEDDDVEKFIEHKAKTKDNKGKLTLQVVSINQNGEFGVPVNNGLKPAREIFVIVTGHDKADVIKKLYEDNGN
TSFIPSSLKTHRMVNVILDEAAAQGLPADVREYFTSLYA

Nucleotide

• Length: 600 bp

>AT240120 NZ_LS992166:670656-671072 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA