Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 975997..976778 Replicon chromosome
Accession NZ_CP094741
Organism Staphylococcus chromogenes strain IVB6200

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag MUA19_RS04685 Protein ID WP_157946118.1
Coordinates 976614..976778 (+) Length 55 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MUA19_RS04680 Protein ID WP_262617389.1
Coordinates 975997..976596 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA19_RS04660 (MUA19_04645) 972181..972903 + 723 WP_262617384.1 amino acid ABC transporter ATP-binding protein -
MUA19_RS04665 (MUA19_04650) 973191..974324 + 1134 WP_262617386.1 tRNA epoxyqueuosine(34) reductase QueG -
MUA19_RS04670 (MUA19_04655) 974321..974791 + 471 WP_232195961.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUA19_RS04675 (MUA19_04660) 974809..975978 + 1170 WP_262617388.1 N-acetylglucosamine-6-phosphate deacetylase -
MUA19_RS04680 (MUA19_04665) 975997..976596 + 600 WP_262617389.1 glucosamine-6-phosphate isomerase Antitoxin
MUA19_RS04685 (MUA19_04670) 976614..976778 + 165 WP_157946118.1 SAS053 family protein Toxin
MUA19_RS04690 (MUA19_04675) 977317..977727 + 411 WP_105986519.1 hypothetical protein -
MUA19_RS04695 (MUA19_04680) 977872..979257 + 1386 WP_262617392.1 class II fumarate hydratase -
MUA19_RS04700 (MUA19_04685) 979279..980805 + 1527 WP_262617393.1 exopolyphosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(135-197)


Sequences

Toxin        


Download         Length: 55 a.a.        Molecular weight: 6306.69 Da        Isoelectric Point: 3.9165

>T240120 WP_157946118.1 NZ_CP094741:976614-976778 [Staphylococcus chromogenes]
MTEEKHIEHENEMVDDFDDLVSLGKEMEQISEANDEEKVNQTHDASIRSDKTEE

Download         Length: 165 bp

>T240120 NZ_LS992166:670345-670659 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22353.33 Da        Isoelectric Point: 6.3860

>AT240120 WP_262617389.1 NZ_CP094741:975997-976596 [Staphylococcus chromogenes]
MAMNFKVFKDKDTAAIYAADIIRKQFNNNPTTIAGFHLSGEEAPVLDYLKRNVDDHAVDFSQIHVLDYDKQTSYFKALGV
PEKQIHKIPEDDDVEKFIEHKAKTKDNKGKLTLQVVSINQNGEFGVPVNNGLKPAREIFVIVTGHDKADVIKKLYEDNGN
TSFIPSSLKTHRMVNVILDEAAAQGLPADVREYFTSLYA

Download         Length: 600 bp

>AT240120 NZ_LS992166:670656-671072 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References