240119

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 835944..836468 Replicon chromosome
Accession NZ_CP094741
Organism Staphylococcus chromogenes strain IVB6200

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUA19_RS03880 Protein ID WP_105987057.1
Coordinates 836115..836468 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag MUA19_RS03875 Protein ID WP_105987058.1
Coordinates 835944..836114 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA19_RS03850 (MUA19_03830) 831792..832265 + 474 WP_262617282.1 PH domain-containing protein -
MUA19_RS03855 (MUA19_03835) 832258..833736 + 1479 WP_262617283.1 PH domain-containing protein -
MUA19_RS03860 (MUA19_03840) 833733..834248 + 516 WP_262617284.1 PH domain-containing protein -
MUA19_RS03865 (MUA19_03845) 834245..834595 + 351 WP_037577181.1 holo-ACP synthase -
MUA19_RS03870 (MUA19_03850) 834711..835859 + 1149 WP_105987059.1 alanine racemase -
MUA19_RS03875 (MUA19_03855) 835944..836114 + 171 WP_105987058.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA19_RS03880 (MUA19_03860) 836115..836468 + 354 WP_105987057.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA19_RS03885 (MUA19_03865) 836532..837536 + 1005 WP_262617285.1 PP2C family protein-serine/threonine phosphatase -
MUA19_RS03890 (MUA19_03870) 837617..837943 + 327 WP_037577172.1 anti-sigma factor antagonist -
MUA19_RS03895 (MUA19_03875) 837946..838425 + 480 WP_232195729.1 anti-sigma B factor RsbW -
MUA19_RS03900 (MUA19_03880) 838400..839170 + 771 WP_037577167.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13106.38 Da        Isoelectric Point: 10.5461

>T240119 WP_105987057.1 NZ_CP094741:836115-836468 [Staphylococcus chromogenes]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSDKKMREVNAALGISLGLHMNQHK

Download         Length: 354 bp

>T240119 NZ_LS992166:c627463-626999 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6267.91 Da        Isoelectric Point: 4.2313

>AT240119 WP_105987058.1 NZ_CP094741:835944-836114 [Staphylococcus chromogenes]
MSAFNQTRVKSLEQSLKEGYVQMADLNLSLATEAYSVECEACDCNESHLLSNHKDD

Download         Length: 171 bp

>AT240119 NZ_LS992166:c627798-627463 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References