Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF-MazE
Location 2324074..2324678 Replicon chromosome
Accession NZ_CP094740
Organism Staphylococcus delphini strain IVB6190

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MUA44_RS11125 Protein ID WP_262612852.1
Coordinates 2324340..2324678 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MUA44_RS11120 Protein ID WP_262612851.1
Coordinates 2324074..2324343 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA44_RS11100 (MUA44_11080) 2319614..2320324 + 711 WP_262612850.1 trypsin-like serine protease -
MUA44_RS11105 (MUA44_11085) 2320485..2322026 - 1542 WP_019166288.1 SLC13 family permease -
MUA44_RS11110 (MUA44_11090) 2322609..2323070 - 462 WP_019166289.1 threonine/serine exporter family protein -
MUA44_RS11115 (MUA44_11095) 2323083..2323838 - 756 WP_173673943.1 threonine/serine exporter family protein -
MUA44_RS11120 (MUA44_11100) 2324074..2324343 + 270 WP_262612851.1 AbrB family transcriptional regulator Antitoxin
MUA44_RS11125 (MUA44_11105) 2324340..2324678 + 339 WP_262612852.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA44_RS11130 (MUA44_11110) 2324888..2325643 - 756 WP_096593340.1 heme-dependent peroxidase -
MUA44_RS11135 (MUA44_11115) 2325811..2326800 + 990 WP_262612853.1 phosphate acetyltransferase -
MUA44_RS11140 (MUA44_11120) 2326800..2327636 + 837 WP_019166295.1 lipoate--protein ligase family protein -
MUA44_RS11145 (MUA44_11125) 2327744..2328148 - 405 WP_096593346.1 arsenate reductase (thioredoxin) -
MUA44_RS11150 (MUA44_11130) 2328164..2329453 - 1290 WP_262612854.1 arsenite efflux transporter membrane subunit ArsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-106)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13095.26 Da        Isoelectric Point: 9.3796

>T240118 WP_262612852.1 NZ_CP094740:2324340-2324678 [Staphylococcus delphini]
MSIKQFDIIYIDLNPTRGREKQNIRPCLVINNQMMIDGTEFVWVVPIINRELRYPTDIELKTKKGLVSGLIDTIQMRALD
LNAHQHHYKDALQDNLKSKVLKAIQTYLNPNY

Download         Length: 339 bp

>T240118 NZ_LS992166:204012-204119 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10021.17 Da        Isoelectric Point: 4.6151

>AT240118 WP_262612851.1 NZ_CP094740:2324074-2324343 [Staphylococcus delphini]
MTQTFNDVSKSTERIFKNGNSQAMSLSKKTIQFVDFEIGDTVEVQKINGGLFITKKEVSIEDSIKNFFQNGGKYQESEVD
FGESVGREI

Download         Length: 270 bp

>AT240118 NZ_LS992166:c203963-203900 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References