Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 895757..896281 Replicon chromosome
Accession NZ_CP094740
Organism Staphylococcus delphini strain IVB6190

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag MUA44_RS04015 Protein ID WP_014613379.1
Coordinates 895928..896281 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag MUA44_RS04010 Protein ID WP_014613378.1
Coordinates 895757..895927 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA44_RS03985 (MUA44_03980) 891647..892120 + 474 WP_262613378.1 PH domain-containing protein -
MUA44_RS03990 (MUA44_03985) 892113..893642 + 1530 WP_262613379.1 PH domain-containing protein -
MUA44_RS03995 (MUA44_03990) 893620..894144 + 525 WP_262616144.1 PH domain-containing protein -
MUA44_RS04000 (MUA44_03995) 894141..894491 + 351 WP_019165830.1 holo-ACP synthase -
MUA44_RS04005 (MUA44_04000) 894525..895673 + 1149 WP_262613381.1 alanine racemase -
MUA44_RS04010 (MUA44_04005) 895757..895927 + 171 WP_014613378.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA44_RS04015 (MUA44_04010) 895928..896281 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA44_RS04020 (MUA44_04015) 896339..897343 + 1005 WP_019165832.1 PP2C family protein-serine/threonine phosphatase -
MUA44_RS04025 (MUA44_04020) 897422..897748 + 327 WP_014613381.1 anti-sigma factor antagonist -
MUA44_RS04030 (MUA44_04025) 897748..898227 + 480 WP_026067010.1 anti-sigma B factor RsbW -
MUA44_RS04035 (MUA44_04030) 898202..898972 + 771 WP_019165834.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T240117 WP_014613379.1 NZ_CP094740:895928-896281 [Staphylococcus delphini]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T240117 NZ_LS991421:c2508250-2507867 [Lacticaseibacillus zeae]
ATGGATGTAACCGTAAAACGCGGAGATGTATTCTTCGCCGATTTATCGCCGGTTGTCGGATCCGAACAGGGTGGCAATCG
ACCTGTACTTATTATTCAAAATAACGTTGGTAACCACTACAGCCCTACGGTTATTGTGGCGGCCATTACCTCCAAGATTC
AGAAACCCAAGATGCCCACTCATGTTGGCTTACGGGCAAAACAAGATGGGGTTGAACGTAACTCGGTGATTTTGCTAGAA
CAGATTCGCACCATCGATAAGCAGCGATTACAGGCGCGCGTGACGGCTTTATCAAGCGCAAAAATGGCGGCCGTTGATCG
TGCGTTAGCAATTTCAGTAGGGCTGGTTAGTTTGCCCAAGCCAAAAACATACAATAAAAATTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT240117 WP_014613378.1 NZ_CP094740:895757-895927 [Staphylococcus delphini]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT240117 NZ_LS991421:c2508517-2508269 [Lacticaseibacillus zeae]
ATGAAGAAGCAAACGTCAGTAACGGTAACGTTTGATGCTGCTATTAAGGCGCGGTTAGATGCCTATTGTGAGTTGAATGA
CACGGATACTCAAGATGTGATCACGACAGCAGTGGCCAAATTTTTGCAGTCACAAGCACCCGATATCAACCAGCTGATTT
CCGGCTACGTTGCCATGGGACAGATCAATACAGAGATCAGTCATGCTTTCTCCGCCTGCGAAAGTGAGGCATACGCCCAT
ATTCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References