Detailed information of TA system TA240116

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 880839..881360
• Replicon: chromosome
• Accession: NZ_CP094740
• Organism: Staphylococcus delphini strain IVB6190

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: MUA44_RS03940
• Protein ID: WP_096543014.1
• Coordinates: 881139..881360 (+)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: A0A2A4GP16
• Locus tag: MUA44_RS03935
• Protein ID: WP_019165818.1
• Coordinates: 880839..881126 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA44_RS03910 (MUA44_03905)	876099..876902	+	804	WP_262613371.1	hydroxyethylthiazole kinase	-
MUA44_RS03915 (MUA44_03910)	876892..877530	+	639	WP_096556492.1	thiamine phosphate synthase	-
MUA44_RS03920 (MUA44_03915)	877619..878485	+	867	WP_019165815.1	membrane protein insertase YidC	-
MUA44_RS03925 (MUA44_03920)	878540..879196	-	657	WP_262613373.1	HD domain-containing protein	-
MUA44_RS03930 (MUA44_03925)	879217..880707	-	1491	WP_262613374.1	cardiolipin synthase	-
MUA44_RS03935 (MUA44_03930)	880839..881126	+	288	WP_019165818.1	copper-sensing transcriptional repressor CsoR	Antitoxin
MUA44_RS03940 (MUA44_03935)	881139..881360	+	222	WP_096543014.1	heavy metal-associated domain-containing protein	Toxin
MUA44_RS03945 (MUA44_03940)	881364..881570	+	207	WP_019165820.1	cation transporter	-
MUA44_RS03950 (MUA44_03945)	881671..883851	+	2181	WP_262613375.1	heavy metal translocating P-type ATPase	-
MUA44_RS03955 (MUA44_03950)	883937..884083	+	147	WP_014613367.1	Lmo0850 family protein	-
MUA44_RS03960 (MUA44_03955)	885052..885780	+	729	WP_262613376.1	peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (21-64)

Antitoxin

• Metal-sensitive transcriptional repressor (3-93)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8107.18 Da
• Isoelectric Point: 4.3480

>T240116 WP_096543014.1 NZ_CP094740:881139-881360 [Staphylococcus delphini]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVVIDLATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSHKGV

Nucleotide

• Length: 222 bp

>T240116 NZ_LS483523:1455930-1456184 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCGACAAGACGATTCATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGAAAGCCCCAAGACAACACGGAAAGGTTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGCAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTATTCTAGAAGTTGGTCATCGG
AGAGATATTTATTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11000.61 Da
• Isoelectric Point: 6.7507

>AT240116 WP_019165818.1 NZ_CP094740:880839-881126 [Staphylococcus delphini]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALNSVASRLLDHHMKGCIMHKIDAGHQDE
AMEELLVTFQKLMKD

Nucleotide

• Length: 288 bp

>AT240116 NZ_LS483523:1455686-1455928 [Streptococcus pneumoniae]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGGAGGATGAA
TAA

Structures

Antitoxin

• AlphaFold DB: A0A2A4GP16