240115

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1135131..1135934 Replicon chromosome
Accession NZ_CP094739
Organism Staphylococcus delphini strain IVB6219

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA39_RS05575 Protein ID WP_262604814.1
Coordinates 1135131..1135592 (-) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA39_RS05580 Protein ID WP_262604815.1
Coordinates 1135605..1135934 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA39_RS05555 (MUA39_05540) 1131264..1132247 - 984 WP_262616054.1 DUF3644 domain-containing protein -
MUA39_RS05560 1132415..1132597 - 183 WP_262616053.1 hypothetical protein -
MUA39_RS05565 (MUA39_05545) 1133628..1133885 - 258 WP_262620243.1 FlgT C-terminal domain-containing protein -
MUA39_RS05570 (MUA39_05550) 1134191..1135090 - 900 WP_262620244.1 HIRAN domain-containing protein -
MUA39_RS05575 (MUA39_05555) 1135131..1135592 - 462 WP_262604814.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUA39_RS05580 (MUA39_05560) 1135605..1135934 - 330 WP_262604815.1 helix-turn-helix transcriptional regulator Antitoxin
MUA39_RS05585 (MUA39_05565) 1136126..1136371 + 246 WP_096543105.1 helix-turn-helix transcriptional regulator -
MUA39_RS05590 (MUA39_05570) 1136386..1137141 + 756 WP_262604816.1 phage antirepressor KilAC domain-containing protein -
MUA39_RS05595 (MUA39_05575) 1137156..1137380 + 225 WP_262586880.1 hypothetical protein -
MUA39_RS05600 (MUA39_05580) 1137383..1137559 - 177 WP_194746656.1 hypothetical protein -
MUA39_RS05605 (MUA39_05585) 1137644..1138087 + 444 WP_262619832.1 hypothetical protein -
MUA39_RS05610 (MUA39_05590) 1138100..1138294 + 195 WP_262619831.1 hypothetical protein -
MUA39_RS05615 (MUA39_05595) 1138440..1138613 + 174 WP_262620300.1 hypothetical protein -
MUA39_RS05620 (MUA39_05600) 1138600..1138980 - 381 WP_262616045.1 DUF2513 domain-containing protein -
MUA39_RS05625 (MUA39_05605) 1139071..1139212 + 142 Protein_1071 hypothetical protein -
MUA39_RS05630 (MUA39_05610) 1139205..1139414 - 210 WP_262612040.1 hypothetical protein -
MUA39_RS05635 (MUA39_05615) 1139484..1139714 + 231 WP_262612041.1 hypothetical protein -
MUA39_RS05640 (MUA39_05620) 1139716..1139925 + 210 WP_262619830.1 hypothetical protein -
MUA39_RS05645 (MUA39_05625) 1140195..1140455 + 261 WP_262619829.1 DUF1108 family protein -
MUA39_RS05650 (MUA39_05630) 1140467..1140685 + 219 WP_262612044.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA 1125580..1180100 54520


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(17-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18136.70 Da        Isoelectric Point: 5.9343

>T240115 WP_262604814.1 NZ_CP094739:c1135592-1135131 [Staphylococcus delphini]
MGLYEETLIQHDYIDVREANVLPDDLDGVWLGDLILIKRNLPEKKKVEVLFEELAHHKLTYGDITNQKQFNNRKFENYAR
RYSYEKSMPLSGIVQAFEQGVHNLYELANFFEISEGHVLDCIEHYKKKYGLQVKYGKYLIRFEPLTIYKDLAD

Download         Length: 462 bp

>T240115 NZ_LS483523:1018519-1018773 [Streptococcus pneumoniae]
ATGCTGCTCAAGTTTACAGAAGATGCCTGGGCAGATTATTGCTACTGGCAAAACCAAGATAAAAAAACACTAAAAAGAAT
CAATAAATTAATCAAGGATATTCAACGCGATCCATTTACAGGAATAGGAAAACCAGAGCCACTCAAATATGATTACCAAG
GAGCCTGGTCACGGCGTATTGATGCAGAAAATCGCTTGATTTATATGATGGATGGAGATAGCGTGGCTTTCTTGTCCTTT
AAAGATCATTACTAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12712.40 Da        Isoelectric Point: 9.3985

>AT240115 WP_262604815.1 NZ_CP094739:c1135934-1135605 [Staphylococcus delphini]
MRNNDEIITIIKASMKKQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQEQPQH
RAAHLEGELTDEEWQRVLDYADYIRSKRK

Download         Length: 330 bp

>AT240115 NZ_LS483523:1018261-1018515 [Streptococcus pneumoniae]
ATGGAAGCAGTCCTTTACTCAACATTCCGAAATCATTTAAAGGACTACATGAAGAAGGTAAATGATGAATTTGAGCCTTT
GACGGTGGTCAATAAAAATCCAGATGAGGACATTGTAGTCCTTTCAAAGAGTGAGTGGGATAGTATCCAAGAAACCCTGA
GAATTGCTCAAAATAAGGAACTTTCTGATAAGGTTTTGCGAGGAATGGCTCAAGTTCGTGCTGGAAGTACTCAGGTCCAT
GTTATTGAGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References