240114

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 919847..920371 Replicon chromosome
Accession NZ_CP094739
Organism Staphylococcus delphini strain IVB6219

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag MUA39_RS04355 Protein ID WP_014613379.1
Coordinates 920018..920371 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag MUA39_RS04350 Protein ID WP_014613378.1
Coordinates 919847..920017 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA39_RS04325 (MUA39_04310) 915737..916210 + 474 WP_096597952.1 PH domain-containing protein -
MUA39_RS04330 (MUA39_04315) 916203..917732 + 1530 WP_262611919.1 PH domain-containing protein -
MUA39_RS04335 (MUA39_04320) 917710..918234 + 525 WP_262622322.1 PH domain-containing protein -
MUA39_RS04340 (MUA39_04325) 918231..918581 + 351 WP_262611921.1 holo-ACP synthase -
MUA39_RS04345 (MUA39_04330) 918615..919763 + 1149 WP_262611922.1 alanine racemase -
MUA39_RS04350 (MUA39_04335) 919847..920017 + 171 WP_014613378.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA39_RS04355 (MUA39_04340) 920018..920371 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA39_RS04360 (MUA39_04345) 920429..921433 + 1005 WP_262611923.1 PP2C family protein-serine/threonine phosphatase -
MUA39_RS04365 (MUA39_04350) 921512..921838 + 327 WP_096597944.1 anti-sigma factor antagonist -
MUA39_RS04370 (MUA39_04355) 921838..922317 + 480 WP_262611924.1 anti-sigma B factor RsbW -
MUA39_RS04375 (MUA39_04360) 922292..923062 + 771 WP_019165834.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T240114 WP_014613379.1 NZ_CP094739:920018-920371 [Staphylococcus delphini]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T240114 NZ_LS483523:956932-957111 [Streptococcus pneumoniae]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAGAAGCAAGGGGAAAGACTTATCACAATCCCTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGTTGGGTTGTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT240114 WP_014613378.1 NZ_CP094739:919847-920017 [Staphylococcus delphini]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT240114 NZ_LS483523:957148-957600 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGATGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATAAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References