240113

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 905107..905628 Replicon chromosome
Accession NZ_CP094739
Organism Staphylococcus delphini strain IVB6219

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MUA39_RS04280 Protein ID WP_262611912.1
Coordinates 905407..905628 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MUA39_RS04275 Protein ID WP_262611911.1
Coordinates 905107..905394 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA39_RS04250 (MUA39_04235) 900368..901171 + 804 WP_262611909.1 hydroxyethylthiazole kinase -
MUA39_RS04255 (MUA39_04240) 901161..901799 + 639 WP_096649784.1 thiamine phosphate synthase -
MUA39_RS04260 (MUA39_04245) 901888..902754 + 867 WP_096543018.1 membrane protein insertase YidC -
MUA39_RS04265 (MUA39_04250) 902808..903464 - 657 WP_262611910.1 HD domain-containing protein -
MUA39_RS04270 (MUA39_04255) 903485..904975 - 1491 WP_096597966.1 cardiolipin synthase -
MUA39_RS04275 (MUA39_04260) 905107..905394 + 288 WP_262611911.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA39_RS04280 (MUA39_04265) 905407..905628 + 222 WP_262611912.1 heavy metal-associated domain-containing protein Toxin
MUA39_RS04285 (MUA39_04270) 905632..905838 + 207 WP_262611913.1 cation transporter -
MUA39_RS04290 (MUA39_04275) 905939..908119 + 2181 WP_262611914.1 heavy metal translocating P-type ATPase -
MUA39_RS04295 (MUA39_04280) 908205..908351 + 147 WP_014613367.1 Lmo0850 family protein -
MUA39_RS04300 (MUA39_04285) 909116..909877 + 762 WP_262611915.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(12-90)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8133.21 Da        Isoelectric Point: 4.1528

>T240113 WP_262611912.1 NZ_CP094739:905407-905628 [Staphylococcus delphini]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVVIDLATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSYKGV

Download         Length: 222 bp

>T240113 NZ_LS483522:1565934-1566269 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCATAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCTGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11001.60 Da        Isoelectric Point: 6.4854

>AT240113 WP_262611911.1 NZ_CP094739:905107-905394 [Staphylococcus delphini]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALDSVASRLLDHHMKGCIMHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT240113 NZ_LS483522:1565657-1565944 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References