Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1116741..1117541 Replicon chromosome
Accession NZ_CP094738
Organism Staphylococcus delphini strain IVB6220

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA34_RS05465 Protein ID WP_262612033.1
Coordinates 1116741..1117199 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA34_RS05470 Protein ID WP_262604815.1
Coordinates 1117212..1117541 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA34_RS05430 (MUA34_05415) 1112860..1113480 + 621 WP_262612026.1 hypothetical protein -
MUA34_RS05435 (MUA34_05420) 1113477..1113632 - 156 WP_262612027.1 hypothetical protein -
MUA34_RS05440 (MUA34_05425) 1113750..1114280 - 531 WP_262612028.1 hypothetical protein -
MUA34_RS05445 (MUA34_05430) 1114363..1114677 - 315 WP_262612029.1 hypothetical protein -
MUA34_RS05450 (MUA34_05435) 1114670..1115182 - 513 WP_262612030.1 hypothetical protein -
MUA34_RS05455 (MUA34_05440) 1115290..1116237 - 948 WP_262612031.1 Abi family protein -
MUA34_RS05460 (MUA34_05445) 1116364..1116735 - 372 WP_262612032.1 hypothetical protein -
MUA34_RS05465 (MUA34_05450) 1116741..1117199 - 459 WP_262612033.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUA34_RS05470 (MUA34_05455) 1117212..1117541 - 330 WP_262604815.1 helix-turn-helix transcriptional regulator Antitoxin
MUA34_RS05475 (MUA34_05460) 1117733..1117978 + 246 WP_096543105.1 helix-turn-helix transcriptional regulator -
MUA34_RS05480 (MUA34_05465) 1117993..1118748 + 756 WP_262612034.1 phage antirepressor KilAC domain-containing protein -
MUA34_RS05485 (MUA34_05470) 1118760..1119026 + 267 WP_262612035.1 DUF2829 domain-containing protein -
MUA34_RS05490 (MUA34_05475) 1119016..1119327 - 312 WP_262612036.1 hypothetical protein -
MUA34_RS05495 (MUA34_05480) 1119389..1120147 + 759 WP_262612037.1 phage antirepressor -
MUA34_RS05500 (MUA34_05485) 1120158..1120385 + 228 WP_262612038.1 DUF2829 domain-containing protein -
MUA34_RS05505 (MUA34_05490) 1120645..1120785 + 141 WP_262612039.1 hypothetical protein -
MUA34_RS05510 (MUA34_05495) 1120778..1120987 - 210 WP_262612040.1 hypothetical protein -
MUA34_RS05515 (MUA34_05500) 1121057..1121287 + 231 WP_262612041.1 hypothetical protein -
MUA34_RS05520 (MUA34_05505) 1121289..1121498 + 210 WP_262612042.1 hypothetical protein -
MUA34_RS05525 (MUA34_05510) 1121768..1121983 + 216 WP_262612043.1 DUF1108 family protein -
MUA34_RS05530 (MUA34_05515) 1122040..1122258 + 219 WP_262612044.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - lukD / hlgA 1109841..1161351 51510


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(32-116)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 18017.53 Da        Isoelectric Point: 5.5940

>T240112 WP_262612033.1 NZ_CP094738:c1117199-1116741 [Staphylococcus delphini]
MGLYEETLIQHDYIEVREANVLPDDLDGVWLGDLILIKRNLPEKKKVEVLFEELAHHKLTYGDITNQKQFNNRKFENYAR
RYSYETSMPLSGIVQAFEQGVHNLYELANFFEISEGHVLDCIEHYKNKYGLQVKYGKYLIRLEPLTIYKNLE

Download         Length: 459 bp

>T240112 NZ_LS483521:1549323-1549658 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGCCATTATCACAGCACTAAAGGTTACACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCGAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12712.40 Da        Isoelectric Point: 9.3985

>AT240112 WP_262604815.1 NZ_CP094738:c1117541-1117212 [Staphylococcus delphini]
MRNNDEIITIIKASMKKQNLSLSELARRVGVAKSAVSRYLNLTREFPLNRAEDFAKALSISTEYLLGFEKSEQKQEQPQH
RAAHLEGELTDEEWQRVLDYADYIRSKRK

Download         Length: 330 bp

>AT240112 NZ_LS483521:1549046-1549333 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References