Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 915552..916076 Replicon chromosome
Accession NZ_CP094738
Organism Staphylococcus delphini strain IVB6220

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag MUA34_RS04310 Protein ID WP_014613379.1
Coordinates 915723..916076 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag MUA34_RS04305 Protein ID WP_014613378.1
Coordinates 915552..915722 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA34_RS04280 (MUA34_04265) 911442..911915 + 474 WP_096597952.1 PH domain-containing protein -
MUA34_RS04285 (MUA34_04270) 911908..913437 + 1530 WP_262611919.1 PH domain-containing protein -
MUA34_RS04290 (MUA34_04275) 913421..913939 + 519 WP_262611920.1 PH domain-containing protein -
MUA34_RS04295 (MUA34_04280) 913936..914286 + 351 WP_262611921.1 holo-ACP synthase -
MUA34_RS04300 (MUA34_04285) 914320..915468 + 1149 WP_262611922.1 alanine racemase -
MUA34_RS04305 (MUA34_04290) 915552..915722 + 171 WP_014613378.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA34_RS04310 (MUA34_04295) 915723..916076 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA34_RS04315 (MUA34_04300) 916134..917138 + 1005 WP_262611923.1 PP2C family protein-serine/threonine phosphatase -
MUA34_RS04320 (MUA34_04305) 917217..917543 + 327 WP_096597944.1 anti-sigma factor antagonist -
MUA34_RS04325 (MUA34_04310) 917543..918022 + 480 WP_262611924.1 anti-sigma B factor RsbW -
MUA34_RS04330 (MUA34_04315) 917997..918767 + 771 WP_019165834.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T240111 WP_014613379.1 NZ_CP094738:915723-916076 [Staphylococcus delphini]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T240111 NZ_LS483521:830922-831689 [Streptococcus pyogenes]
ATGCGGTTAGAAGAATTTAGTCAAGATGACTTTGACTTAGCCTTAAAACGAACTATTCGTTCCTTAACTCGTGGTAAAAC
GACATCAGTAACCCCAAAAGCCATCTTACTTGGTAGGCAAAGCGGAGCGGGAAAAACAACGATTCACCGTATCAAGCAGA
AAGAGTTCCAAGGGAATATCATTATCATTGACGGCGATAGCTATCGTCCTTTACACCCAAATTATCTAGATTTGCAAGAG
AAGTATGGCAAGGATAGCGTGGATTATACCAAAGGTTTTGCAGAGAAAATGGTGGAACAGCTTGTGGATGAACTCAGTAA
ACAAGGTTATCATTTGTTAATCGAAGGAACTTTGAGAACGACAGAAGTCCCAAGAAAAACAGCTCGGCTATTGAAATCAC
GAGGCTATCAAGTCTCACTAGCATTGATAGCAACTAAGCCTGAATTGTCCTATCTCAGCACCTTAATTCGTTACGAGGAA
GTCTATGCCGTAAATCCAAATCAAGCTAGAGCAACCCCTAAAGGGCATCACGATGGTATTGTAGAGCGTTTAGTTGATAA
CTTACGAGAGTTAGAAACTAATAAACTCTTTGACCAGATTCAAATATATCAAAGAGATAGAACCTGTGTCTATGATTCTG
AAACAGATGAAGGTCCAGCTGCCGATGTTCTGCAAGATTGCCTCTTTGGAAAGTGGAGTAAGGTGGAGGAGGAGATGTTA
AGGGATATAGAAGAGAAAATAGCTAATTTAAAGGTTAGCAATGAATAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT240111 WP_014613378.1 NZ_CP094738:915552-915722 [Staphylococcus delphini]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT240111 NZ_LS483521:830446-830922 [Streptococcus pyogenes]
ATGATTGGAGATAATATCAAATCGTTACGTAAAACCCATGATTTAACACAACCAGAATTCGCAAAGATTGTTGGAATTTC
ACGAAATAGCCTTAGTCGTTATGAAAATGGGACAAGCTCTGTTTCAACAGAACTGATAGACCGTATTTGTCAGAAATTCA
ACGTGTCTTATGTTGATATTGTAGGAGAAGAAAAAATGTTAACACCAGTAGAAGATTATCAATTAACGCTAAAAATAGAA
GTCATTAAAGAGCGAGGCGCAGCGATTTTATCCCAACTGTATCGCTATCAAGATAGTCAAAAAATTGCTTTTGACGATGA
AACCAATCCTTGGATTTTGATGAGTGATGATTTGTCTGATCTTATCAATACCAAGATTTATCTTGTTCAATCGTTTGATG
AAGTGGAGCGTTACAATGGTTATTTAGATGGTATTGAGCGAATATTGAATCTTGCTCATCATCAGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References