Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 900812..901333 Replicon chromosome
Accession NZ_CP094738
Organism Staphylococcus delphini strain IVB6220

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag MUA34_RS04235 Protein ID WP_262611912.1
Coordinates 901112..901333 (+) Length 74 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag MUA34_RS04230 Protein ID WP_262611911.1
Coordinates 900812..901099 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA34_RS04205 (MUA34_04190) 896073..896876 + 804 WP_262611909.1 hydroxyethylthiazole kinase -
MUA34_RS04210 (MUA34_04195) 896866..897504 + 639 WP_096649784.1 thiamine phosphate synthase -
MUA34_RS04215 (MUA34_04200) 897593..898459 + 867 WP_096543018.1 membrane protein insertase YidC -
MUA34_RS04220 (MUA34_04205) 898513..899169 - 657 WP_262611910.1 HD domain-containing protein -
MUA34_RS04225 (MUA34_04210) 899190..900680 - 1491 WP_096597966.1 cardiolipin synthase -
MUA34_RS04230 (MUA34_04215) 900812..901099 + 288 WP_262611911.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUA34_RS04235 (MUA34_04220) 901112..901333 + 222 WP_262611912.1 heavy metal-associated domain-containing protein Toxin
MUA34_RS04240 (MUA34_04225) 901337..901543 + 207 WP_262611913.1 cation transporter -
MUA34_RS04245 (MUA34_04230) 901644..903824 + 2181 WP_262611914.1 heavy metal translocating P-type ATPase -
MUA34_RS04250 (MUA34_04235) 903910..904056 + 147 WP_014613367.1 Lmo0850 family protein -
MUA34_RS04255 (MUA34_04240) 904821..905582 + 762 WP_262611915.1 peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(21-64)

Antitoxin

Metal-sensitive transcriptional repressor

(12-90)


Sequences

Toxin        


Download         Length: 74 a.a.        Molecular weight: 8133.21 Da        Isoelectric Point: 4.1528

>T240110 WP_262611912.1 NZ_CP094738:901112-901333 [Staphylococcus delphini]
MENGYVKVTQLTTEAQQQQLSDRLLRLIGVESVVIDLATQSLTLTYDTPANLNTIEKEIYDAGFPVIQSYKGV

Download         Length: 222 bp

>T240110 NZ_LS483520:c1777996-1777727 [Streptococcus pyogenes]
ATGACTTATAAGCTAGTGGTGAGTGATGAAGTCAAGAAGCAACTCAAAAAGATGGATAAACATGTAGGGCTTATGTTAGC
CAAAGACATGAAGAAACGACTTGACGGGTTAAATAATCCTAGACAATTTGGAAAAGCCCTCACAGGTCAATATAAAGGAC
TTTGGCGCTATCGTGTTGGTAATTATCGGGTGATTTGTGACATTGTGGATAATGAAATGATTATCCTTGCTTTGGAAGTT
GGACACAGGAAAGAGATATACAAGCGCTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11001.60 Da        Isoelectric Point: 6.4854

>AT240110 WP_262611911.1 NZ_CP094738:900812-901099 [Staphylococcus delphini]
MTEQAHHSEEIKRNLKSRLNRIEGQVKAINRMIDEDVYCDDVLTQIRATRSALDSVASRLLDHHMKGCIMHKIDAGHQDE
AMEELLVTFQKLMKD

Download         Length: 288 bp

>AT240110 NZ_LS483520:c1778213-1777986 [Streptococcus pyogenes]
ATGGCAATGGTATCATTAAGACTGAACAGCGCAGAGGAAGAACTTTTCAGAAGCTACGCTACACACACAGGCAAAACATT
ATCTGAATTATTCAAGACAGCACTAGCACAACAAATTGAAGATCAATTGGACTATGAAACAGGTATTCAAGCTTTAAAAC
GCTTTGAAGAAAATCCCATAACTTATTCTATCGATGATTTAATTGAGGAGTTGGAAAATGACTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References