Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 856388..856912 Replicon chromosome
Accession NZ_CP094736
Organism Staphylococcus delphini strain IVB6222

Toxin (Protein)


Gene name mazF Uniprot ID A0A2A4EDC7
Locus tag MUA33_RS04070 Protein ID WP_014613379.1
Coordinates 856559..856912 (+) Length 118 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A166MM16
Locus tag MUA33_RS04065 Protein ID WP_014613378.1
Coordinates 856388..856558 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA33_RS04040 (MUA33_04030) 852278..852751 + 474 WP_096597952.1 PH domain-containing protein -
MUA33_RS04045 (MUA33_04035) 852744..854273 + 1530 WP_262611919.1 PH domain-containing protein -
MUA33_RS04050 (MUA33_04040) 854251..854775 + 525 WP_262622322.1 PH domain-containing protein -
MUA33_RS04055 (MUA33_04045) 854772..855122 + 351 WP_019165830.1 holo-ACP synthase -
MUA33_RS04060 (MUA33_04050) 855156..856304 + 1149 WP_262631158.1 alanine racemase -
MUA33_RS04065 (MUA33_04055) 856388..856558 + 171 WP_014613378.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUA33_RS04070 (MUA33_04060) 856559..856912 + 354 WP_014613379.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA33_RS04075 (MUA33_04065) 856970..857974 + 1005 WP_019165832.1 PP2C family protein-serine/threonine phosphatase -
MUA33_RS04080 (MUA33_04070) 858053..858379 + 327 WP_096597944.1 anti-sigma factor antagonist -
MUA33_RS04085 (MUA33_04075) 858379..858858 + 480 WP_262611924.1 anti-sigma B factor RsbW -
MUA33_RS04090 (MUA33_04080) 858833..859603 + 771 WP_019165834.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13130.36 Da        Isoelectric Point: 10.4439

>T240109 WP_014613379.1 NZ_CP094736:856559-856912 [Staphylococcus delphini]
MKRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKNKYKLDKDSVILLEQIRT
VDKKRLKEKLTFLSEKKMKEVNNAIGISLGLHMNHHK

Download         Length: 354 bp

>T240109 NZ_LS483520:1615947-1616282 [Streptococcus pyogenes]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGCTAAAAGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCAACATCAGGTCAGCGTAAAATGGAGCAAATCATTAGCGACATAGAAAAACTCGAGGTTTTCCCAGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCATCCTTTATCACAGCACTAAAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGGGGAAGAAAATAGGGTCGTTATTGATTACTTGCTTCCTACTCAAAGCGACTATAT
AAAGTTATTCAAATAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6396.04 Da        Isoelectric Point: 3.9930

>AT240109 WP_014613378.1 NZ_CP094736:856388-856558 [Staphylococcus delphini]
MSAFNQTRFKNLEQSLKEGYVQMADLNLSLATEAYPVECEACDCNESHLTTDYKED

Download         Length: 171 bp

>AT240109 NZ_LS483520:1615670-1615957 [Streptococcus pyogenes]
ATGACTACAGTAAAAAAAAACAGAGCGGTTACCTTTCAAGCTAATAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAAAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTACAAAATGTCGTTGTCACAAACGAGGTTGACTTATTGA
CGGAAGAGGAGTTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAGGATGTTCGTCAA
GGGAAGTTTTATACCTCTGAAGAAGTGAGGGCTGAACTTGGACTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A4EDC7

Antitoxin

Source ID Structure
AlphaFold DB A0A166MM16

References