Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) pemIK/MazF-MazE
Location 2367154..2367758 Replicon chromosome
Accession NZ_CP094734
Organism Staphylococcus delphini strain IVB6245

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag MUA22_RS11425 Protein ID WP_262612852.1
Coordinates 2367420..2367758 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag MUA22_RS11420 Protein ID WP_262612851.1
Coordinates 2367154..2367423 (+) Length 90 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA22_RS11400 (MUA22_11385) 2362694..2363404 + 711 WP_262612850.1 trypsin-like serine protease -
MUA22_RS11405 (MUA22_11390) 2363565..2365106 - 1542 WP_019166288.1 SLC13 family permease -
MUA22_RS11410 (MUA22_11395) 2365689..2366150 - 462 WP_019166289.1 threonine/serine exporter family protein -
MUA22_RS11415 (MUA22_11400) 2366163..2366918 - 756 WP_173673943.1 threonine/serine exporter family protein -
MUA22_RS11420 (MUA22_11405) 2367154..2367423 + 270 WP_262612851.1 AbrB family transcriptional regulator Antitoxin
MUA22_RS11425 (MUA22_11410) 2367420..2367758 + 339 WP_262612852.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUA22_RS11430 (MUA22_11415) 2367968..2368723 - 756 WP_096593340.1 heme-dependent peroxidase -
MUA22_RS11435 (MUA22_11420) 2368891..2369880 + 990 WP_262612853.1 phosphate acetyltransferase -
MUA22_RS11440 (MUA22_11425) 2369880..2370716 + 837 WP_019166295.1 lipoate--protein ligase family protein -
MUA22_RS11445 (MUA22_11430) 2370824..2371228 - 405 WP_096593346.1 arsenate reductase (thioredoxin) -
MUA22_RS11450 (MUA22_11435) 2371244..2372533 - 1290 WP_262612854.1 arsenite efflux transporter membrane subunit ArsB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-106)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 113 a.a.        Molecular weight: 13095.26 Da        Isoelectric Point: 9.3796

>T240107 WP_262612852.1 NZ_CP094734:2367420-2367758 [Staphylococcus delphini]
MSIKQFDIIYIDLNPTRGREKQNIRPCLVINNQMMIDGTEFVWVVPIINRELRYPTDIELKTKKGLVSGLIDTIQMRALD
LNAHQHHYKDALQDNLKSKVLKAIQTYLNPNY

Download         Length: 339 bp

>T240107 NZ_LS483518:c1056980-1056246 [Mycoplasma mycoides subsp. capri]
CTGAAAAAAATATCTAAGAATAAGGATAAGATAAATATCATATTTAAAGGAGGTTTTTTGCTTTCTAATATAATTGGAAT
AAAAGAAAGAACAACCAAAGATATTGATTATTTATTAAATAACATTGTATTTTCACCTGATCGTATAAAAGAATTATTTG
AAGATATTTTAGATTATAAGAAAGGAGATAAAATACATTTTCAAATTCAAAAAATAAATGAAATTAAGAAAAAAGAAAAA
TATACAGGTTTTAGAATAACTGTAGAATGCAAATTAGATGAAATAGTAGAAATTATAAAAATAGATGTAGCAACAGGTGA
TATCATCACTTCCTGTCAAGTTAGATATAATATTGAAAATATTTTTCATAACAACAGTTTTTATGTTTATGGTTATAACT
TAGAAACTATGTTGGCTGAAAAAATTCATGCAATCAAAGAATTAAGCTTGTTTAATACTAGAACAAAAGATTTCTATGAT
ATATACCTAATTTATAATTTAAAAAGAGATGATATTGACTATATGACGTTGAAAAATGCTTGTATTAATACATTCAAACA
AAGAAACAGCATTTTTGATAAAGACGATTTATTAGAGTTACTCAATAAAATAAAAAATTCGCAATCTACTCATAATTTAT
GAACTAAACAAAAAAATATATATTTTTATAATAAAAACATAGATTTTAAATTTATCATTCAGTCAATTATTGAACTTATT
AAAAACATTAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10021.17 Da        Isoelectric Point: 4.6151

>AT240107 WP_262612851.1 NZ_CP094734:2367154-2367423 [Staphylococcus delphini]
MTQTFNDVSKSTERIFKNGNSQAMSLSKKTIQFVDFEIGDTVEVQKINGGLFITKKEVSIEDSIKNFFQNGGKYQESEVD
FGESVGREI

Download         Length: 270 bp

>AT240107 NZ_LS483518:c1057679-1057080 [Mycoplasma mycoides subsp. capri]
ATGAACTATGTAGAAAAAATAAAAGAAAAAGCCATTCAAAATAATGGACTAATAACAAGAAAAGAAATTATAAGTCTAAA
AATCCCACCTATTTATATAACTAGAATGGTAAGAAAAAAAGAACTTGAAAAAATTGATATTGGAATTTATGCACTAACTT
CACTAGATAATTATCCTTACGATCCCGAATTTAATTTTTGTTCAAGATATCAAGTTCCTGTTTTTTCATATGTTTATGCA
TTAAACTTATTTGATTTTACTGATGTTATTCCACTTAATTTTGAAGTAACTGTTTATAAAGGGTATAATGCACATAATCT
TAAACCTAACACAATAGTTCACTATGTTAATAAAGAAATTTTTAATCTAGGAATTACTGAAATTAGAAATGCTTTTGGAA
ATTGGGTAAGAACCTATGATATTGAAAGAACAATTTGTGATCTTATTAAAAATAGAAAAAATATTAATGTTGAACTTTTT
GTAAAAACTATGAATAACTATGTTAATTATGAAAAAAAGGACTGGAATAAACTTTATGAATATGCTGAAAAAATGCACAT
TGAAAAAGAGCTAGTAGAAATATTTCAACTTATTATTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References