Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pemIK/MazF-MazE |
Location | 2367154..2367758 | Replicon | chromosome |
Accession | NZ_CP094734 | ||
Organism | Staphylococcus delphini strain IVB6245 |
Toxin (Protein)
Gene name | pemK | Uniprot ID | - |
Locus tag | MUA22_RS11425 | Protein ID | WP_262612852.1 |
Coordinates | 2367420..2367758 (+) | Length | 113 a.a. |
Antitoxin (Protein)
Gene name | pemI | Uniprot ID | - |
Locus tag | MUA22_RS11420 | Protein ID | WP_262612851.1 |
Coordinates | 2367154..2367423 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MUA22_RS11400 (MUA22_11385) | 2362694..2363404 | + | 711 | WP_262612850.1 | trypsin-like serine protease | - |
MUA22_RS11405 (MUA22_11390) | 2363565..2365106 | - | 1542 | WP_019166288.1 | SLC13 family permease | - |
MUA22_RS11410 (MUA22_11395) | 2365689..2366150 | - | 462 | WP_019166289.1 | threonine/serine exporter family protein | - |
MUA22_RS11415 (MUA22_11400) | 2366163..2366918 | - | 756 | WP_173673943.1 | threonine/serine exporter family protein | - |
MUA22_RS11420 (MUA22_11405) | 2367154..2367423 | + | 270 | WP_262612851.1 | AbrB family transcriptional regulator | Antitoxin |
MUA22_RS11425 (MUA22_11410) | 2367420..2367758 | + | 339 | WP_262612852.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
MUA22_RS11430 (MUA22_11415) | 2367968..2368723 | - | 756 | WP_096593340.1 | heme-dependent peroxidase | - |
MUA22_RS11435 (MUA22_11420) | 2368891..2369880 | + | 990 | WP_262612853.1 | phosphate acetyltransferase | - |
MUA22_RS11440 (MUA22_11425) | 2369880..2370716 | + | 837 | WP_019166295.1 | lipoate--protein ligase family protein | - |
MUA22_RS11445 (MUA22_11430) | 2370824..2371228 | - | 405 | WP_096593346.1 | arsenate reductase (thioredoxin) | - |
MUA22_RS11450 (MUA22_11435) | 2371244..2372533 | - | 1290 | WP_262612854.1 | arsenite efflux transporter membrane subunit ArsB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 113 a.a. Molecular weight: 13095.26 Da Isoelectric Point: 9.3796
>T240107 WP_262612852.1 NZ_CP094734:2367420-2367758 [Staphylococcus delphini]
MSIKQFDIIYIDLNPTRGREKQNIRPCLVINNQMMIDGTEFVWVVPIINRELRYPTDIELKTKKGLVSGLIDTIQMRALD
LNAHQHHYKDALQDNLKSKVLKAIQTYLNPNY
MSIKQFDIIYIDLNPTRGREKQNIRPCLVINNQMMIDGTEFVWVVPIINRELRYPTDIELKTKKGLVSGLIDTIQMRALD
LNAHQHHYKDALQDNLKSKVLKAIQTYLNPNY
Download Length: 339 bp
>T240107 NZ_LS483518:c1056980-1056246 [Mycoplasma mycoides subsp. capri]
CTGAAAAAAATATCTAAGAATAAGGATAAGATAAATATCATATTTAAAGGAGGTTTTTTGCTTTCTAATATAATTGGAAT
AAAAGAAAGAACAACCAAAGATATTGATTATTTATTAAATAACATTGTATTTTCACCTGATCGTATAAAAGAATTATTTG
AAGATATTTTAGATTATAAGAAAGGAGATAAAATACATTTTCAAATTCAAAAAATAAATGAAATTAAGAAAAAAGAAAAA
TATACAGGTTTTAGAATAACTGTAGAATGCAAATTAGATGAAATAGTAGAAATTATAAAAATAGATGTAGCAACAGGTGA
TATCATCACTTCCTGTCAAGTTAGATATAATATTGAAAATATTTTTCATAACAACAGTTTTTATGTTTATGGTTATAACT
TAGAAACTATGTTGGCTGAAAAAATTCATGCAATCAAAGAATTAAGCTTGTTTAATACTAGAACAAAAGATTTCTATGAT
ATATACCTAATTTATAATTTAAAAAGAGATGATATTGACTATATGACGTTGAAAAATGCTTGTATTAATACATTCAAACA
AAGAAACAGCATTTTTGATAAAGACGATTTATTAGAGTTACTCAATAAAATAAAAAATTCGCAATCTACTCATAATTTAT
GAACTAAACAAAAAAATATATATTTTTATAATAAAAACATAGATTTTAAATTTATCATTCAGTCAATTATTGAACTTATT
AAAAACATTAAATAG
CTGAAAAAAATATCTAAGAATAAGGATAAGATAAATATCATATTTAAAGGAGGTTTTTTGCTTTCTAATATAATTGGAAT
AAAAGAAAGAACAACCAAAGATATTGATTATTTATTAAATAACATTGTATTTTCACCTGATCGTATAAAAGAATTATTTG
AAGATATTTTAGATTATAAGAAAGGAGATAAAATACATTTTCAAATTCAAAAAATAAATGAAATTAAGAAAAAAGAAAAA
TATACAGGTTTTAGAATAACTGTAGAATGCAAATTAGATGAAATAGTAGAAATTATAAAAATAGATGTAGCAACAGGTGA
TATCATCACTTCCTGTCAAGTTAGATATAATATTGAAAATATTTTTCATAACAACAGTTTTTATGTTTATGGTTATAACT
TAGAAACTATGTTGGCTGAAAAAATTCATGCAATCAAAGAATTAAGCTTGTTTAATACTAGAACAAAAGATTTCTATGAT
ATATACCTAATTTATAATTTAAAAAGAGATGATATTGACTATATGACGTTGAAAAATGCTTGTATTAATACATTCAAACA
AAGAAACAGCATTTTTGATAAAGACGATTTATTAGAGTTACTCAATAAAATAAAAAATTCGCAATCTACTCATAATTTAT
GAACTAAACAAAAAAATATATATTTTTATAATAAAAACATAGATTTTAAATTTATCATTCAGTCAATTATTGAACTTATT
AAAAACATTAAATAG
Antitoxin
Download Length: 90 a.a. Molecular weight: 10021.17 Da Isoelectric Point: 4.6151
>AT240107 WP_262612851.1 NZ_CP094734:2367154-2367423 [Staphylococcus delphini]
MTQTFNDVSKSTERIFKNGNSQAMSLSKKTIQFVDFEIGDTVEVQKINGGLFITKKEVSIEDSIKNFFQNGGKYQESEVD
FGESVGREI
MTQTFNDVSKSTERIFKNGNSQAMSLSKKTIQFVDFEIGDTVEVQKINGGLFITKKEVSIEDSIKNFFQNGGKYQESEVD
FGESVGREI
Download Length: 270 bp
>AT240107 NZ_LS483518:c1057679-1057080 [Mycoplasma mycoides subsp. capri]
ATGAACTATGTAGAAAAAATAAAAGAAAAAGCCATTCAAAATAATGGACTAATAACAAGAAAAGAAATTATAAGTCTAAA
AATCCCACCTATTTATATAACTAGAATGGTAAGAAAAAAAGAACTTGAAAAAATTGATATTGGAATTTATGCACTAACTT
CACTAGATAATTATCCTTACGATCCCGAATTTAATTTTTGTTCAAGATATCAAGTTCCTGTTTTTTCATATGTTTATGCA
TTAAACTTATTTGATTTTACTGATGTTATTCCACTTAATTTTGAAGTAACTGTTTATAAAGGGTATAATGCACATAATCT
TAAACCTAACACAATAGTTCACTATGTTAATAAAGAAATTTTTAATCTAGGAATTACTGAAATTAGAAATGCTTTTGGAA
ATTGGGTAAGAACCTATGATATTGAAAGAACAATTTGTGATCTTATTAAAAATAGAAAAAATATTAATGTTGAACTTTTT
GTAAAAACTATGAATAACTATGTTAATTATGAAAAAAAGGACTGGAATAAACTTTATGAATATGCTGAAAAAATGCACAT
TGAAAAAGAGCTAGTAGAAATATTTCAACTTATTATTTAA
ATGAACTATGTAGAAAAAATAAAAGAAAAAGCCATTCAAAATAATGGACTAATAACAAGAAAAGAAATTATAAGTCTAAA
AATCCCACCTATTTATATAACTAGAATGGTAAGAAAAAAAGAACTTGAAAAAATTGATATTGGAATTTATGCACTAACTT
CACTAGATAATTATCCTTACGATCCCGAATTTAATTTTTGTTCAAGATATCAAGTTCCTGTTTTTTCATATGTTTATGCA
TTAAACTTATTTGATTTTACTGATGTTATTCCACTTAATTTTGAAGTAACTGTTTATAAAGGGTATAATGCACATAATCT
TAAACCTAACACAATAGTTCACTATGTTAATAAAGAAATTTTTAATCTAGGAATTACTGAAATTAGAAATGCTTTTGGAA
ATTGGGTAAGAACCTATGATATTGAAAGAACAATTTGTGATCTTATTAAAAATAGAAAAAATATTAATGTTGAACTTTTT
GTAAAAACTATGAATAACTATGTTAATTATGAAAAAAAGGACTGGAATAAACTTTATGAATATGCTGAAAAAATGCACAT
TGAAAAAGAGCTAGTAGAAATATTTCAACTTATTATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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