Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 2295103..2295890 Replicon chromosome
Accession NZ_CP094733
Organism Staphylococcus epidermidis strain IVB6194

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA15_RS11075 Protein ID WP_002469089.1
Coordinates 2295429..2295890 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUA15_RS11070 Protein ID WP_002469093.1
Coordinates 2295103..2295417 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA15_RS11015 (MUA15_10985) 2290312..2291013 - 702 WP_002439167.1 helix-turn-helix domain-containing protein -
MUA15_RS11020 (MUA15_10990) 2291010..2291684 - 675 WP_262619619.1 putative HNHc nuclease -
MUA15_RS11025 (MUA15_10995) 2291698..2292114 - 417 WP_002469453.1 single-stranded DNA-binding protein -
MUA15_RS11030 (MUA15_11000) 2292107..2292733 - 627 WP_002469464.1 DUF1071 domain-containing protein -
MUA15_RS11035 (MUA15_11005) 2292726..2292950 - 225 WP_047499927.1 DUF2483 family protein -
MUA15_RS11040 (MUA15_11010) 2292922..2293197 - 276 WP_047499924.1 chordopoxvirus fusion protein -
MUA15_RS11045 (MUA15_11015) 2293252..2293428 - 177 WP_180339535.1 hypothetical protein -
MUA15_RS11050 (MUA15_11020) 2293567..2293773 + 207 WP_237629863.1 hypothetical protein -
MUA15_RS11055 (MUA15_11025) 2293759..2293923 - 165 WP_002469098.1 hypothetical protein -
MUA15_RS11060 (MUA15_11030) 2293926..2294699 - 774 WP_002469090.1 phage regulatory protein/antirepressor Ant -
MUA15_RS11065 (MUA15_11035) 2294713..2294949 - 237 WP_002469095.1 helix-turn-helix transcriptional regulator -
MUA15_RS11070 (MUA15_11040) 2295103..2295417 + 315 WP_002469093.1 helix-turn-helix transcriptional regulator Antitoxin
MUA15_RS11075 (MUA15_11045) 2295429..2295890 + 462 WP_002469089.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUA15_RS11080 (MUA15_11050) 2295909..2296385 + 477 WP_262619620.1 hypothetical protein -
MUA15_RS11085 (MUA15_11055) 2296387..2296869 + 483 WP_262619621.1 hypothetical protein -
MUA15_RS11090 (MUA15_11060) 2296923..2298299 + 1377 WP_262619622.1 recombinase family protein -
MUA15_RS11095 (MUA15_11065) 2298326..2299528 + 1203 Protein_2155 FAD-dependent oxidoreductase -
MUA15_RS11100 (MUA15_11070) 2299918..2300259 - 342 WP_001832090.1 DUF1450 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2228352..2298299 69947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(32-120)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18229.87 Da        Isoelectric Point: 6.4966

>T240104 WP_002469089.1 NZ_CP094733:2295429-2295890 [Staphylococcus epidermidis]
MGLYEKMLIEHDYIEVRETNVMPNNLHGLWLGDLILIKRNLSEVRKAEVLYEELAHHKLTYGNILDQSKFNNRKFENYAR
RYGYEAALPLRILVEAHNYGVSNLYELAEYVQLSEEYIAEILKHYKNKYGIGTNYGEYLITFDPLRVFKYKEI

Download         Length: 462 bp

>T240104 NZ_LS483515:c1057109-1056375 [Mycoplasma mycoides subsp. capri]
CTGAAAAAAATATCTAAGAATAAGGATAAGATAAATATCATATTTAAAGGAGGTTTTTTGCTTTCTAATATAATTGGAAT
AAAAGAAAGAACAACCAAAGATATTGATTATTTATTAAATAACATTGTATTTTCACCTGATCGTATAAAAGAATTATTTG
AAGATATTTTAGATTATAAGAAAGGAGATAAAATACATTTTCAAATTCAAAAAATAAATGAAATTAAGAAAAAAGAAAAA
TATACAGGTTTTAGAATAACTGTAGAATGCAAATTAGATGAAATAGTAGAAATTATAAAAATAGATGTAGCAACAGGTGA
TATCATCACTTCCTGTCAAGTTAGATATAATATTGAAAATATTTTTCATAACAACAGTTTTTATGTTTATGGTTATAACT
TAGAAACTATGTTGGCTGAAAAAATTCATGCAATCAAAGAATTAAGCTTGTTTAATACTAGAACAAAAGATTTCTATGAT
ATATACCTAATTTATAATTTAAAAAGAGATGATATTGACTATATGACGTTGAAAAATGCTTGTATTAATACATTCAAACA
AAGAAACAGCATTTTTGATAAAGACGATTTATTAGAGTTACTCAATAAAATAAAAAATTCGCAATCTACTCATAATTTAT
GAACTAAACAAAAAAATATATATTTTTATAATAAAAACATAGATTTTAAATTTATCATTCAGTCAATTATTGAACTTATT
AAAAACATTAAATAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12045.59 Da        Isoelectric Point: 7.1669

>AT240104 WP_002469093.1 NZ_CP094733:2295103-2295417 [Staphylococcus epidermidis]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAFLMGWIDESDEQPQHRAAHL
EGELTDEEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT240104 NZ_LS483515:c1057808-1057209 [Mycoplasma mycoides subsp. capri]
ATGAACTATGTAGAAAAAATAAAAGAAAAAGCCATTCAAAATAATGGACTAATAACAAGAAAAGAAATTATAAGTCTAAA
AATCCCACCTATTTATATAACTAGAATGGTAAGAAAAAAAGAACTTGAAAAAATTGATATTGGAATTTATGCACTAACTT
CACTAGATAATTATCCTTACGATCCCGAATTTAATTTTTGTTCAAGATATCAAGTTCCTGTTTTTTCATATGTTTATGCA
TTAAACTTATTTGATTTTACTGATGTTATTCCACTTAATTTTGAAGTAACTGTTTATAAAGGGTATAATGCACATAATCT
TAAACCTAACACAATAGTTCACTATGTTAATAAAGAAATTTTTAATCTAGGAATTACTGAAATTAGAAATGCTTTTGGAA
ATTGGGTAAGAACCTATGATATTGAAAGAACAATTTGTGATCTTATTAAAAATAGAAAAAATATTAATGTTGAACTTTTT
GTAAAAACTATGAATAACTATGTTAATTATGAAAAAAAGGACTGGAATAAACTTTATGAATATGCTGAAAAAATGCACAT
TGAAAAAGAGCTAGTAGAAATATTTCAACTTATTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References