Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2035760..2036230 Replicon chromosome
Accession NZ_CP094733
Organism Staphylococcus epidermidis strain IVB6194

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag MUA15_RS09705 Protein ID WP_001829569.1
Coordinates 2036042..2036230 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag MUA15_RS09700 Protein ID WP_002438963.1
Coordinates 2035760..2036017 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUA15_RS09660 (MUA15_09630) 2031126..2031842 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
MUA15_RS09665 (MUA15_09635) 2032003..2032425 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
MUA15_RS09670 (MUA15_09640) 2032609..2032746 - 138 WP_162161215.1 hypothetical protein -
MUA15_RS09675 (MUA15_09645) 2032776..2032963 - 188 Protein_1873 hypothetical protein -
MUA15_RS09680 (MUA15_09650) 2033350..2033850 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
MUA15_RS09685 (MUA15_09655) 2034121..2034708 - 588 WP_001829615.1 histidine phosphatase family protein -
MUA15_RS09690 (MUA15_09660) 2034920..2035156 + 237 WP_002457224.1 hypothetical protein -
MUA15_RS09695 (MUA15_09665) 2035148..2035351 - 204 WP_002438966.1 sterile alpha motif-like domain-containing protein -
MUA15_RS09700 (MUA15_09670) 2035760..2036017 + 258 WP_002438963.1 hypothetical protein Antitoxin
MUA15_RS09705 (MUA15_09675) 2036042..2036230 + 189 WP_001829569.1 hypothetical protein Toxin
MUA15_RS09710 (MUA15_09680) 2036420..2036973 + 554 Protein_1880 hypothetical protein -
MUA15_RS09715 (MUA15_09685) 2037033..2037266 - 234 WP_001829664.1 hypothetical protein -
MUA15_RS09720 (MUA15_09690) 2037550..2038296 + 747 WP_002438959.1 poly-gamma-glutamate hydrolase family protein -
MUA15_RS09725 (MUA15_09695) 2038395..2038679 + 285 WP_001829635.1 hypothetical protein -
MUA15_RS09730 (MUA15_09700) 2038703..2038927 + 225 WP_001829613.1 hypothetical protein -
MUA15_RS09735 (MUA15_09705) 2039548..2039748 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - clpP 2026734..2067967 41233
- flank IS/Tn - - 2032609..2032764 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(4-210)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(5-53)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T240103 WP_001829569.1 NZ_CP094733:2036042-2036230 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T240103 NZ_LS483514:c1056976-1056242 [Mycoplasma mycoides subsp. capri]
CTGAAAAAAATATCTAAGAATAAGGATAAGATAAATATCATATTTAAAGGAGGTTTTTTGCTTTCTAATATAATTGGAAT
AAAAGAAAGAACAACCAAAGATATTGATTATTTATTAAATAACATTGTATTTTCACCTGATCGTATAAAAGAATTATTTG
AAGATATTTTAGATTATAAGAAAGGAGATAAAATACATTTTCAAATTCAAAAAATAAATGAAATTAAGAAAAAAGAAAAA
TATACAGGTTTTAGAATAACTGTAGAATGCAAATTAGATGAAATAGTAGAAATTATAAAAATAGATGTAGCAACAGGTGA
TATCATCACTTCCTGTCAAGTTAGATATAATATTGAAAATATTTTTCATAACAACAGTTTTTATGTTTATGGTTATAACT
TAGAAACTATGTTGGCTGAAAAAATTCATGCAATCAAAGAATTAAGCTTGTTTAATACTAGAACAAAAGATTTCTATGAT
ATATACCTAATTTATAATTTAAAAAGAGATGATATTGACTATATGACGTTGAAAAATGCTTGTATTAATACATTCAAACA
AAGAAACAGCATTTTTGATAAAGACGATTTATTAGAGTTACTCAATAAAATAAAAAATTCGCAATCTACTCATAATTTAT
GAACTAAACAAAAAAATATATATTTTTATAATAAAAACATAGATTTTAAATTTATCATTCAGTCAATTATTGAACTTATT
AAAAACATTAAATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT240103 WP_002438963.1 NZ_CP094733:2035760-2036017 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT240103 NZ_LS483514:c1057675-1057076 [Mycoplasma mycoides subsp. capri]
ATGAACTATGTAGAAAAAATAAAAGAAAAAGCCATTCAAAATAATGGACTAATAACAAGAAAAGAAATTATAAGTCTAAA
AATCCCACCTATTTATATAACTAGAATGGTAAGAAAAAAAGAACTTGAAAAAATTGATATTGGAATTTATGCACTAACTT
CACTAGATAATTATCCTTACGATCCCGAATTTAATTTTTGTTCAAGATATCAAGTTCCTGTTTTTTCATATGTTTATGCA
TTAAACTTATTTGATTTTACTGATGTTATTCCACTTAATTTTGAAGTAACTGTTTATAAAGGGTATAATGCACATAATCT
TAAACCTAACACAATAGTTCACTATGTTAATAAAGAAATTTTTAATCTAGGAATTACTGAAATTAGAAATGCTTTTGGAA
ATTGGGTAAGAACCTATGATATTGAAAGAACAATTTGTGATCTTATTAAAAATAGAAAAAATATTAATGTTGAACTTTTT
GTAAAAACTATGAATAACTATGTTAATTATGAAAAAAAGGACTGGAATAAACTTTATGAATATGCTGAAAAAATGCACAT
TGAAAAAGAGCTAGTAGAAATATTTCAACTTATTATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References